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Metabolic Enzyme/Protease
Farnesyl Transferase
Tipifarnib S enantiomer - 98%, high purity , CAS No.192185-71-0

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Tipifarnib S enantiomer - 98%, high purity , CAS No.192185-71-0

COA

Grade & Purity:

≥98%

Cas Number: 192185-71-0
Molecular Weight: 489.4
PubChem CID: 9935249

In stock

Item Number

T412364

Grouped product items
SKU	Size	Availability	Price
T412364-1mg	1mg	3	$74.90
T412364-5mg	5mg	3	$171.90
T412364-10mg	10mg	2	$276.90
T412364-25mg	25mg	1	$499.90

View related series

Amino Acid/Protein Metabolism (1836) Farnesyl Transferase (27) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	(S)-(-)-R-115777,IND-58359 S enantiomer
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Tipifarnib S enantiomer ((S)-(-)-R-115777,IND-58359 S enantiomer) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Tipifarnib S enantiomer ((S)-(-)-R-115777,IND-58359 S enantiomer) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Diarylheptanoids
    - Subclass Linear diarylheptanoids

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Diarylheptanoids
Subclass	Linear diarylheptanoids
Intermediate Tree Nodes	Not available
Direct Parent	Linear diarylheptanoids
Alternative Parents	Phenylquinolines Phenylpyridines Hydroquinolones Hydroquinolines Pyridinones Aralkylamines Chlorobenzenes Aryl chlorides N-substituted imidazoles Heteroaromatic compounds Lactams Azacyclic compounds Hydrocarbon derivatives Monoalkylamines Organic oxides Organochlorides Organooxygen compounds Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Linear 1,7-diphenylheptane skeleton - Phenylquinoline - 4-phenylpyridine - Dihydroquinolone - Dihydroquinoline - Quinoline - Chlorobenzene - Halobenzene - Aralkylamine - Pyridinone - Aryl chloride - Aryl halide - Monocyclic benzene moiety - N-substituted imidazole - Pyridine - Benzenoid - Azole - Heteroaromatic compound - Imidazole - Lactam - Organoheterocyclic compound - Azacycle - Amine - Hydrocarbon derivative - Primary aliphatic amine - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organohalogen compound - Organochloride - Primary amine - Organonitrogen compound - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as linear diarylheptanoids. These are diarylheptanoids with an open heptane chain. The two aromatic rings are linked only by the heptane chain.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

ERG11 Cytochrome P450 51 (617 Activities)

Discover Target: ERG11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	6-[(S)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
INCHI	InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m0/s1
InChIKey	PLHJCIYEEKOWNM-MHZLTWQESA-N
Smiles	CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
Isomeric SMILES	CN1C=NC=C1[C@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
PubChem CID	9935249
Molecular Weight	489.4

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
G2411546	Certificate of Analysis	Mar 28, 2024	T412364
G2411550	Certificate of Analysis	Mar 28, 2024	T412364
G2411547	Certificate of Analysis	Mar 28, 2024	T412364
G2411548	Certificate of Analysis	Mar 28, 2024	T412364
G2411549	Certificate of Analysis	Mar 28, 2024	T412364
G2411551	Certificate of Analysis	Mar 28, 2024	T412364
G2411552	Certificate of Analysis	Mar 28, 2024	T412364
G2411553	Certificate of Analysis	Mar 28, 2024	T412364

Chemical and Physical Properties

Molecular Weight	489.400 g/mol
XLogP3	4.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	488.117 Da
Monoisotopic Mass	488.117 Da
Topological Polar Surface Area	64.200 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	785.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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