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TC-FPR 43 - ≥98%(HPLC), high purity , CAS No.903895-98-7, Agonist of FPR1;Agonist of FPR2/ALX

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 903895-98-7
Molecular Weight: 384.86
PubChem CID: 24776341
PubChem SID: 488200685

In stock

Item Number

T287729

Grouped product items
SKU	Size	Availability	Price
T287729-5mg	5mg	3	$187.90
T287729-10mg	10mg	2	$286.90
T287729-25mg	25mg	1	$563.90
T287729-50mg	50mg	1	$899.90
T287729-100mg	100mg	1	$1,434.90

Potent FPR2 agonist

View related series

Class A GPCR (4138) Formyl Peptide Receptor (FPR) (17) FPR1 Agonist (23) FPR2/ALX Agonist (41) GPCR/G Protein (3172)

Basic Description

Synonyms	BDBM59086 \| 1-(4-chlorophenyl)-3-(1-methyl-3-oxo-2-phenyl-5-propan-2-ylpyrazol-4-yl)urea \| ()-Alminoprofen;EB 382; Minalfene \| CS-0015852 \| HY-19574 \| MFCD30182236 \| N-(4-chlorophenyl)-N'-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-y
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent formyl peptide receptor 2 (FPR2) agonist (EC50= 44 nM). Inhibits fMLP- and IL-8-induced neutrophil migration. Suppresses inflammation in a mouse model of acute inflammation. Orally bioavailable.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of FPR1;Agonist of FPR2/ALX
Product Description	Product description FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azoles
    - Subclass Pyrazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azoles
Subclass	Pyrazoles
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyrazoles
Alternative Parents	N-phenylureas Chlorobenzenes Pyrazolones Aryl chlorides Vinylogous amides Heteroaromatic compounds Ureas Lactams Azacyclic compounds Organonitrogen compounds Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Phenylpyrazole - N-phenylurea - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Pyrazolinone - Heteroaromatic compound - Vinylogous amide - Urea - Lactam - Azacycle - Organohalogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organochloride - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

FPR1 Tchem fMet-Leu-Phe receptor (1 Activities)

Discover Target: FPR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 (2 Activities)

Discover Target: FPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488200685
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200685
IUPAC Name	1-(4-chlorophenyl)-3-(1-methyl-3-oxo-2-phenyl-5-propan-2-ylpyrazol-4-yl)urea
INCHI	InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
InChIKey	PAEBEUZTAPIOIO-UHFFFAOYSA-N
Smiles	CC(C)C1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
Isomeric SMILES	CC(C)C1=C(C(=O)N(N1C)C2=CC=CC=C2)NC(=O)NC3=CC=C(C=C3)Cl
Alternate CAS	903895-98-7
PubChem CID	24776341
Molecular Weight	384.86

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
D2306911	Certificate of Analysis	Feb 07, 2023	T287729
D2306786	Certificate of Analysis	Feb 07, 2023	T287729
D2306908	Certificate of Analysis	Feb 07, 2023	T287729
D2306958	Certificate of Analysis	Feb 07, 2023	T287729
D2306787	Certificate of Analysis	Feb 07, 2023	T287729
D2306960	Certificate of Analysis	Feb 07, 2023	T287729
D2306965	Certificate of Analysis	Feb 07, 2023	T287729
D2306961	Certificate of Analysis	Feb 07, 2023	T287729
D2306966	Certificate of Analysis	Feb 07, 2023	T287729
D2306964	Certificate of Analysis	Feb 07, 2023	T287729

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 38.49, Max Conc. mM: 100
Sensitivity	Moisture sensitive
Molecular Weight	384.900 g/mol
XLogP3	4.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	384.135 Da
Monoisotopic Mass	384.135 Da
Topological Polar Surface Area	64.700 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	593.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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