Skip to the beginning of the images gallery

TAN [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals] - 99%, high purity , CAS No.1147-56-4

COA

Grade & Purity:

≥99%

Cas Number: 1147-56-4
Molecular Weight: 255.3
MDL number: MFCD00021611
PubChem CID: 93572

In stock

Item Number

T162491

Grouped product items
SKU	Size	Availability	Price
T162491-250mg	250mg	3	$27.90
T162491-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$78.90
T162491-5g	5g	1	$325.90

Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein

View related series

Amino Acid/Protein Metabolism (1836) Cell Cycle (2830) Five-Membered Heterocyclic Compounds (2064) Spectroscopic reagent (233)

Basic Description

Synonyms	GCBAKGGJQPMJLL-NTCAYCPXSA- \| 2-Naphthalenol,1-[2-(2-thiazolyl)diazenyl]- \| Acide bromebrique \| (1Z)-1-(2-thiazolylhydrazinylidene)-2-naphthalenone \| 1-(1,3-thiazol-2-yldiazenyl)naphthalen-2-ol \| 1-(2-Thiazolylazo)-2-naphthol \| AKOS015912775 \| EINECS 214-5
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	High affinity Rio Kinase 2 (RIOK2) inhibitor (Kd= 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cellsin vitro(IC50= 169 nM) but not ERG-
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Naphthalenes
    - Subclass Naphthols and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Naphthalenes
Subclass	Naphthols and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Naphthols and derivatives
Alternative Parents	1-hydroxy-2-unsubstituted benzenoids Thiazoles Heteroaromatic compounds Azo compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organooxygen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	2-naphthol - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Azole - Heteroaromatic compound - Thiazole - Azo compound - Azacycle - Organoheterocyclic compound - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha (1 Activities)

Discover Target: HSP90AA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(1,3-thiazol-2-yldiazenyl)naphthalen-2-ol
INCHI	InChI=1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H
InChIKey	IOMXCGDXEUDZAK-UHFFFAOYSA-N
Smiles	C1=CC=C2C(=C1)C=CC(=C2N=NC3=NC=CS3)O
Isomeric SMILES	C1=CC=C2C(=C1)C=CC(=C2N=NC3=NC=CS3)O
PubChem CID	93572
Molecular Weight	255.3
Reaxy-Rn	21172

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
E2430474	Certificate of Analysis	Apr 16, 2024	T162491
E2430456	Certificate of Analysis	Apr 16, 2024	T162491
G2408161	Certificate of Analysis	Mar 15, 2024	T162491
G2408162	Certificate of Analysis	Mar 15, 2024	T162491
G2408164	Certificate of Analysis	Mar 15, 2024	T162491
G2408277	Certificate of Analysis	Mar 15, 2024	T162491
G2408278	Certificate of Analysis	Mar 15, 2024	T162491
G2408279	Certificate of Analysis	Mar 15, 2024	T162491

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 25.53, Max Conc. mM: 100
Melt Point(°C)	141 °C
Molecular Weight	255.300 g/mol
XLogP3	4.000
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	255.047 Da
Monoisotopic Mass	255.047 Da
Topological Polar Surface Area	86.100 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	313.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration