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T0467 - 10mM in DMSO, high purity , CAS No.859518-94-8(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 859518-94-8(DMSO)
Molecular Weight: 441.49

In stock

Item Number

T655522

Grouped product items
SKU	Size	Availability	Price	Qty
T655522-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$363.90

View related series

Compound libraries (12325) Metabolic Enzyme/Protease (4860) Mitochondrial Metabolism (118)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro . T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research. In Vitro T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells. T0467 does not show obvious toxicity in Drosophila at concentrations <50 μM. All cpds examined mitigated the PINK1 inactivation-mediated larval locomotion defects and mitochondrial morphological defects and reduced ATP production. T0467 and KTP improved the mitochondrial Ca 2+ response in Drosophila larval muscles. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Names and Identifiers

Smiles	FC1=CC=C(CN2[C@H](CNCC2)C)C=C1C3=NC(NCCC4=CC(F)=CC(F)=C4)=NC=C3
Molecular Weight	441.49

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