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SYN1143 - 98%, high purity , CAS No.913376-84-8

COA

Grade & Purity:

≥98%

Cas Number: 913376-84-8
Molecular Weight: 556.59
PubChem CID: 16757524
PubChem SID: 488199430

In stock

Item Number

C331456

Grouped product items
SKU	Size	Availability	Price
C331456-5mg	5mg	3	$197.90
C331456-25mg	25mg	2	$632.90
C331456-50mg	50mg	1	$1,018.90
C331456-100mg	100mg	1	$1,632.90

an inhibitor of both Met and Ron

View related series

c-Met/HGFR (76) Protein Tyrosine Kinase/RTK (1314) Receptor Tyrosine Kinase (1260)

Basic Description

Synonyms	BDBM24465 \| N-(3-Fluoro-4-((7-methoxyquinolin-4-yl)oxy)phenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide \| BRD-K29983336-001-01-2 \| Q27163246 \| Substituted Pyrazolone, 7 \| 75H \| RON-IN-1 \| AS-16282 \| CHEBI:
Specifications & Purity	≥98%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SYN1143 is a potent, selective and orally active dual inhibitor of c-Met/RON, with IC50s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on Lck, Tie2, Src, and BTK with IC50s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated。

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Anilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Anilides
Intermediate Tree Nodes	Not available
Direct Parent	Aromatic anilides
Alternative Parents	Diarylethers Phenylpyrazoles Quinolines and derivatives Anisoles Phenoxy compounds Pyrazole-4-carboxamides Alkyl aryl ethers Fluorobenzenes Aryl fluorides Pyridines and derivatives Pyrazolones Heteroaromatic compounds Tertiary alcohols Vinylogous amides Lactams Secondary carboxylic acid amides Azacyclic compounds Organofluorides Organic oxides Hydrocarbon derivatives Organonitrogen compounds Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Aromatic anilide - Diaryl ether - Phenylpyrazole - Quinoline - Phenoxy compound - Anisole - Pyrazole-4-carboxamide - Phenol ether - Halobenzene - Fluorobenzene - Alkyl aryl ether - Aryl fluoride - Aryl halide - Pyrazolinone - Pyridine - Heteroaromatic compound - Azole - Vinylogous amide - Tertiary alcohol - Pyrazole - Carboxamide group - Lactam - Secondary carboxylic acid amide - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Ether - Alcohol - Organopnictogen compound - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R', where R= benzene, and R = aryl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

pKa	pKa: 11 (Predicted), pKa: 5.25 (Predicted)
Ki Data	Met: Ki= 2.7 nM (human); IGF-IRα/β: Ki= 887 nM (human)

Associated Targets(Human)

MET Tclin Hepatocyte growth factor receptor (3 Activities)

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)

Discover Target: IGF1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

Discover Target: KDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MET Tclin Hepatocyte growth factor receptor (10718 Activities)

Discover Target: MET

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488199430
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488199430
IUPAC Name	N-[3-fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide
INCHI	InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(21-8-6-5-7-9-21)35(19)18-31(2,3)39)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(40-4)11-12-23(25)26/h5-17,39H,18H2,1-4H3,(H,34,37)
InChIKey	UYMSIPINLJNNOU-UHFFFAOYSA-N
Smiles	CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC)F
Isomeric SMILES	CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC)F
Molecular Weight	556.59
Reaxy-Rn	12745547
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12745547&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
E2306518	Certificate of Analysis	Mar 27, 2023	C331456
E2306487	Certificate of Analysis	Mar 27, 2023	C331456
E2306526	Certificate of Analysis	Mar 27, 2023	C331456
E2306494	Certificate of Analysis	Mar 27, 2023	C331456
E2306519	Certificate of Analysis	Mar 27, 2023	C331456
E2306522	Certificate of Analysis	Mar 27, 2023	C331456
E2306539	Certificate of Analysis	Mar 27, 2023	C331456
E2306521	Certificate of Analysis	Mar 27, 2023	C331456

Chemical and Physical Properties

Solubility	Soluble in DMSO (40 mg/ml).
Sensitivity	Light sensitive
Refractive Index	n20D1.66 (Predicted)
Molecular Weight	556.600 g/mol
XLogP3	4.800
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	8
Exact Mass	556.212 Da
Monoisotopic Mass	556.212 Da
Topological Polar Surface Area	104.000 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	986.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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