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Metabolic Enzyme/Protease
15-PGDH
SW 033291 - ≥98%(HPLC), high purity , CAS No.459147-39-8

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SW 033291 - ≥98%(HPLC), high purity , CAS No.459147-39-8

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 459147-39-8
Molecular Weight: 412.59
PubChem CID: 3337839
PubChem SID: 504762539

In stock

Item Number

S288218

Grouped product items
SKU	Size	Availability	Price
S288218-5mg	5mg	2	$98.90
S288218-10mg	10mg	2	$147.90
S288218-25mg	25mg	2	$333.90
S288218-50mg	50mg	2	$444.90
S288218-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$642.90
S288218-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,446.90

High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation.

View related series

15-PGDH (5) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	NSC787269 \| s7900 \| SB19146 \| SCHEMBL15525569 \| 2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine \| US9789116, SW033291 \| AC-32909 \| SW033291, >=98% (HPLC) \| 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine \| Z22138
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	SW033291 is an inhibitor of the prostaglandin-degrading enzyme 15-PGDH. PGE2 is known to promote hematopoiesis and to promote reeneration by causing stem cells to proliferate. 15-PGDH degrades prostaglandin PGE2 and is a negative regulator of tissue regen
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Description SW033291 is a selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) with IC50 and Kiapp of 1.5 nM and 0.1 nM, respectively.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Phenylpyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Phenylpyridines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyridines
Alternative Parents	Thienopyridines Benzene and substituted derivatives Aminothiophenes Heteroaromatic compounds Sulfoxides Sulfinyl compounds Azacyclic compounds Primary amines Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	4-phenylpyridine - Thienopyridine - Aminothiophene - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Thiophene - Sulfoxide - Azacycle - Sulfinyl compound - Hydrocarbon derivative - Primary amine - Organic oxide - Organosulfur compound - Organonitrogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (2 Activities)

Discover Target: HPGD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Liver (3974 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

Discover Target: HPGD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504762539
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504762539
IUPAC Name	2-butylsulfinyl-4-phenyl-6-thiophen-2-ylthieno[2,3-b]pyridin-3-amine
INCHI	InChI=1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
InChIKey	LCYAYKSMOVLVRL-UHFFFAOYSA-N
Smiles	CCCCS(=O)C1=C(C2=C(S1)N=C(C=C2C3=CC=CC=C3)C4=CC=CS4)N
Isomeric SMILES	CCCCS(=O)C1=C(C2=C(S1)N=C(C=C2C3=CC=CC=C3)C4=CC=CS4)N
PubChem CID	3337839
Molecular Weight	412.59

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
F2204960	Certificate of Analysis	Mar 04, 2025	S288218
F2204862	Certificate of Analysis	Mar 04, 2025	S288218
F2204863	Certificate of Analysis	Mar 04, 2025	S288218
F2204864	Certificate of Analysis	Mar 04, 2025	S288218
F2204865	Certificate of Analysis	Mar 04, 2025	S288218
F2204866	Certificate of Analysis	Mar 04, 2025	S288218

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 41.26, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 8.25, Max Conc. mM: 20
Melt Point(°C)	>99°C (Dec)
Molecular Weight	412.600 g/mol
XLogP3	5.700
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	412.074 Da
Monoisotopic Mass	412.074 Da
Topological Polar Surface Area	132.000 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	514.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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SW 033291 - ≥98%(HPLC), high purity , CAS No.459147-39-8

Basic Description

Taxonomic Classification

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews