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Sotorasib (AMG510) - 98%, high purity , CAS No.2296729-00-3

1 Citations COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
S414206
Grouped product items
SKU Size
Availability
 Price Qty
S414206-5mg
5mg
5
$15.90
S414206-25mg
25mg
5
$33.90
S414206-100mg
100mg
5
$99.90
S414206-250mg
250mg
5
$169.90
S414206-1g
1g
3
$436.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Ras Inhibitors

View related series
G Protein Related (287) GPCR/G Protein (3172) KRAS (55) Ras (143)

Basic Description

Synonyms 2252403-56-6 | BA172505 | BDBM50514402 | AMG 510 pound>>AMG-510 | BRD-K03981224-001-02-9 | Congestion | SCHEMBL3491 | Kras G12C inhibitor 9 | PYRILAMINE MALEATE [VANDF] | (1m)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)-
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound.
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

Information

Sotorasib (AMG510) Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. This AMG510 is a chiral compound.


Targets

K-Ras(G12C)


In vitro

AMG 510 inhibits SOS1-catalyzed nucleotide exchange of recombinant mutant KRAS (G12C/C118A) but had minimal effect on KRAS (C118A). AMG 510 also selectively impairs the viability of KRAS p.G12C mutant lines but does not affect cell lines with other KRAS mutations.


In vivo

In preclinical tumor models, AMG 510 rapidly and irreversibly binds to KRAS (G12C), providing durable suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. Dosed orally (once daily) as a single agent, AMG 510 is capable of inducing tumor regression in mouse models of KRASG12C cancer.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Pyridines and derivatives
Subclass Phenylpyridines
Intermediate Tree Nodes Not available
Direct Parent Phenylpyridines
Alternative Parents N-arylpiperazines  Pyrido[2,3-d]pyrimidines  M-fluorophenols  Dialkylarylamines  Pyrimidones  Methylpyridines  Fluorobenzenes  Aminopyrimidines and derivatives  1-hydroxy-4-unsubstituted benzenoids  1-hydroxy-2-unsubstituted benzenoids  Imidolactams  Aryl fluorides  Tertiary carboxylic acid amides  Heteroaromatic compounds  Acrylic acids and derivatives  Azacyclic compounds  Organopnictogen compounds  Organofluorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents N-arylpiperazine - 2-phenylpyridine - Pyrido[2,3-d]pyrimidine - Pyridopyrimidine - Dialkylarylamine - 3-fluorophenol - 3-halophenol - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Methylpyridine - Pyrimidone - Phenol - Halobenzene - Fluorobenzene - Aminopyrimidine - Imidolactam - Benzenoid - Pyrimidine - Piperazine - 1,4-diazinane - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Acrylic acid or derivatives - Heteroaromatic compound - Tertiary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Carbonyl group - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
External Descriptors Not available

Associated Targets(Human)

KRAS Tclin GTPase KRas (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
NCI-H1975 (4994 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H358 (882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
A549 (127892 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MIA PaCa-2 (5949 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H23 (49055 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H1792 (313 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
NCI-H2122 (340 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KRAS Tclin GTPase KRas (1864 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504773485
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504773485
IUPAC Name 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
INCHI InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
InChIKey NXQKSXLFSAEQCZ-SFHVURJKSA-N
Smiles CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
Isomeric SMILES C[C@H]1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
PubChem CID 137278711
Molecular Weight 560.59

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

16 results found

Lot Number Certificate Type Date Item
F2230480 Certificate of Analysis Apr 03, 2025 S414206
C2525839 Certificate of Analysis Mar 05, 2025 S414206
C2517586 Certificate of Analysis Mar 05, 2025 S414206
G23261008 Certificate of Analysis Jul 06, 2023 S414206
G2326978 Certificate of Analysis Jul 06, 2023 S414206
G23261007 Certificate of Analysis Jul 06, 2023 S414206
G2326991 Certificate of Analysis Jul 06, 2023 S414206
G23261215 Certificate of Analysis Jul 06, 2023 S414206
G2326170 Certificate of Analysis Jul 06, 2023 S414206
G2326168 Certificate of Analysis Jul 06, 2023 S414206
G23261011 Certificate of Analysis Jul 06, 2023 S414206
G23261010 Certificate of Analysis Jul 06, 2023 S414206
G23261017 Certificate of Analysis Jul 06, 2023 S414206
G2201052 Certificate of Analysis Jun 05, 2022 S414206
F23021202 Certificate of Analysis Jun 05, 2022 S414206
G2219209 Certificate of Analysis Jun 05, 2022 S414206

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Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 100 mg/mL (178.38 mM); Ethanol: 8 mg/mL (14.27 mM); Water: Insoluble;
Molecular Weight 560.600 g/mol
XLogP3 4.000
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 7
Rotatable Bond Count 5
Exact Mass 560.235 Da
Monoisotopic Mass 560.235 Da
Topological Polar Surface Area 102.000 Ų
Heavy Atom Count 41
Formal Charge 0
Complexity 1030.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Alternative Products

  1. Sotorasib (AMG510) racemate, GTPase KRas inhibitor
    Sotorasib (AMG510) racemate, GTPase KRas inhibitor

    Starting at $29.90

  2. Sotorasib (AMG510)
    Sotorasib (AMG510)
    • 10mM in DMSO

    Starting at $84.90

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Yang Chen, Wenzhe Xu, Hao Jin, Mengsi Zhang, Shuwei Liu, Yi Liu, Hao Zhang.  (2024)  Nutritional Glutamine-Modified Iron-Delivery System with Enhanced Endocytosis for Ferroptosis Therapy of Pancreatic Tumors.  ACS Nano,  18  (46): (31846-31868). 

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