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Sotorasib (AMG510) - 10mM in DMSO, high purity , CAS No.2296729-00-3(DMSO)

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Sotorasib (AMG510) - 10mM in DMSO, high purity , CAS No.2296729-00-3(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 2296729-00-3(DMSO)
Molecular Weight: 560.59

In stock

Item Number

S409151

Grouped product items
SKU	Size	Availability	Price	Qty
S409151-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$84.90

Ras Inhibitors

View related series

Compound libraries (12325) KRAS (55)

Basic Description

Synonyms	Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-, (1R)-
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Sotorasib (AMG510) Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. This AMG510 is a chiral compound. In vitro AMG 510 inhibits SOS1-catalyzed nucleotide exchange of recombinant mutant KRAS (G12C/C118A) but had minimal effect on KRAS (C118A). AMG 510 also selectively impairs the viability of KRAS p.G12C mutant lines but does not affect cell lines with other KRAS mutations. In vivo In preclinical tumor models, AMG 510 rapidly and irreversibly binds to KRAS (G12C), providing durable suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. Dosed orally (once daily) as a single agent, AMG 510 is capable of inducing tumor regression in mouse models of KRASG12C cancer. Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥98%

Associated Targets(Human)

KRAS Tclin GTPase KRas (2 Activities)

Discover Target: KRAS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Molecular Weight	560.59

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Documents & Articles

Traditional Chinese Medicine Molecule RA-V: A Potential Synergistic Factor in KRAS G12C Inhibition

Categories: Technical articles

Tags:

KRAS KRAS G12C KRAS-targeted therapy Nrf2/GLS1 signaling pathway Traditional Chinese Medicine

KRAS Inhibitors — The "Undruggable Target"? A Thing of the Past

Categories: Technical articles

Tags:

KRAS KRAS-targeted therapy RAS signaling pathway

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