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SKF 86466 hydrochloride - ≥98%(HPLC), high purity , CAS No.86129-54-6

COA COA
    Grade & Purity:
  • ≥98%(HPLC)
In stock
Item Number
S286807
Grouped product items
SKU Size
Availability
 Price Qty
S286807-5mg
5mg
3
$111.90
S286807-10mg
10mg
3
$211.90
S286807-25mg
25mg
3
$384.90
S286807-50mg
50mg
2
$826.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Potent and selective α2antagonist

View related series
Class A GPCR (4138)

Basic Description

Synonyms DTXSID70436918 | LP01056 | Skf 86466 | SR-01000076121 | 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride | 1H-3-BENZAZEPINE, 6-CHLORO-2,3,4,5-TETRAHYDRO-3-METHYL-, HYDROCHLORIDE (1:1) | Tox21_501056 | SKF-86466 hydrochloride, solid, >=9
Specifications & Purity ≥98%(HPLC)
Biochemical and Physiological Mechanisms Potent and selectiveα2antagonist at pre- and post-junctionalα2-adrenoceptors (Kivalues are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.
Storage Temp Protected from light,Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description

SKF 86466 hydrochloride is a novel selective alpha-2 adrenergic receptor antagonist. Benalfocin reduces blood pressure and heart rate. Benalfocin can be used in the study of cardiovascular effects。

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Benzazepines
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Benzazepines
Alternative Parents Azepines  Aralkylamines  Benzenoids  Aryl chlorides  Trialkylamines  Azacyclic compounds  Organopnictogen compounds  Organochlorides  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Benzazepine - Azepine - Aralkylamine - Aryl chloride - Aryl halide - Benzenoid - Tertiary amine - Tertiary aliphatic amine - Azacycle - Amine - Organonitrogen compound - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as benzazepines. These are organic compounds containing a benzene ring fused to an azepine ring (unsaturated seven-membered heterocycle with one nitrogen atom replacing a carbon atom).
External Descriptors Not available

Associated Targets(Human)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ERG Tbio Transcriptional regulator ERG (5589 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cavia porcellus (23802 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npsr1 Neuropeptide S receptor (260 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 6-chloro-3-methyl-1,2,4,5-tetrahydro-3-benzazepine;hydrochloride
INCHI InChI=1S/C11H14ClN.ClH/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13;/h2-4H,5-8H2,1H3;1H
InChIKey JKQKVNMNAIFCFS-UHFFFAOYSA-N
Smiles CN1CCC2=C(CC1)C(=CC=C2)Cl.Cl
Isomeric SMILES CN1CCC2=C(CC1)C(=CC=C2)Cl.Cl
PubChem CID 10220250
Molecular Weight 232.15

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number Certificate Type Date Item
G2411364 Certificate of Analysis Mar 28, 2024 S286807
G2411395 Certificate of Analysis Mar 28, 2024 S286807
G2411518 Certificate of Analysis Mar 28, 2024 S286807
G2411519 Certificate of Analysis Mar 28, 2024 S286807
G2411520 Certificate of Analysis Mar 28, 2024 S286807
G2411521 Certificate of Analysis Mar 28, 2024 S286807
G2411522 Certificate of Analysis Mar 28, 2024 S286807
G2411523 Certificate of Analysis Mar 28, 2024 S286807

Chemical and Physical Properties

Solubility Solvent:water, Max Conc. mg/mL: 23.21, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 23.21, Max Conc. mM: 100
Sensitivity Light sensitive; Heat sensitive； Moisture sensitive
Molecular Weight 232.150 g/mol
XLogP3
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 1
Rotatable Bond Count 0
Exact Mass 231.058 Da
Monoisotopic Mass 231.058 Da
Topological Polar Surface Area 3.200 Ų
Heavy Atom Count 14
Formal Charge 0
Complexity 171.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Solution Calculators

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