JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

This is a demo store. No orders will be fulfilled.

Account

Settings

Language

྾

Home
Metabolism
Sapropterin dihydrochloride - 98%, high purity , Phenylalanine-4-hydroxylase activator, CAS No.69056-38-8, Phenylalanine-4-hydroxylase activator

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Sapropterin dihydrochloride - 98%, high purity , Phenylalanine-4-hydroxylase activator, CAS No.69056-38-8, Phenylalanine-4-hydroxylase activator

COA

Grade & Purity:

≥98%

Cas Number: 69056-38-8
Molecular Weight: 314.17
MDL number: MFCD00891665
PubChem CID: 135409471
PubChem SID: 504773278

In stock

Item Number

S304404

Grouped product items
SKU	Size	Availability	Price
S304404-10mg	10mg	2	$58.90
S304404-50mg	50mg	3	$94.90
S304404-100mg	100mg	3	$165.90
S304404-250mg	250mg	2	$373.90

Basic Description

Synonyms	Biopten (TN) \| 4-Fluoro-beta-nitrostyrene, >=98.5% (sum of isomers, GC) \| Sapropterin dihydrochloride (USAN) \| (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-1H-pteridin-4-one;dihydrochloride \| AKOS016842774 \| FT-0778245 \| Sapropterin HCl
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	ACTIVATOR
Mechanism of action	Phenylalanine-4-hydroxylase activator
Product Description	Product description Sapropterin ((6R)-BH4) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) Product application (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH4 has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pteridines and derivatives
    - Subclass Pterins and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pteridines and derivatives
Subclass	Pterins and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Biopterins and derivatives
Alternative Parents	Secondary alkylarylamines Pyrimidones Aminopyrimidines and derivatives Vinylogous amides Heteroaromatic compounds 1,3-aminoalcohols Secondary alcohols 1,2-diols 1,2-aminoalcohols Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Biopterin - Aminopyrimidine - Pyrimidone - Secondary aliphatic/aromatic amine - Pyrimidine - 1,3-aminoalcohol - Heteroaromatic compound - Vinylogous amide - 1,2-aminoalcohol - 1,2-diol - Secondary alcohol - Azacycle - Secondary amine - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Amine - Alcohol - Organopnictogen compound - Hydrochloride - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as biopterins and derivatives. These are coenzymes containing a 2-amino-pteridine-4-one derivative. They are mainly synthesized in several parts of the body, including the pineal gland.
External Descriptors	hydrochloride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504773278
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773278
IUPAC Name	(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one;dihydrochloride
INCHI	InChI=1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
InChIKey	RKSUYBCOVNCALL-NTVURLEBSA-N
Smiles	CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O.Cl.Cl
Isomeric SMILES	C[C@@H]([C@@H]([C@H]1CNC2=C(N1)C(=O)NC(=N2)N)O)O.Cl.Cl
PubChem CID	135409471
Molecular Weight	314.17

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
E2408019	Certificate of Analysis	Nov 21, 2022	S304404
C2308071	Certificate of Analysis	Nov 21, 2022	S304404
B2426129	Certificate of Analysis	Nov 21, 2022	S304404
C2308062	Certificate of Analysis	Nov 21, 2022	S304404
C2308061	Certificate of Analysis	Nov 21, 2022	S304404
C2308070	Certificate of Analysis	Nov 21, 2022	S304404
C2514267	Certificate of Analysis	Nov 21, 2022	S304404

Chemical and Physical Properties

Sensitivity	Moisture sensitive
Molecular Weight	314.170 g/mol
XLogP3
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	313.071 Da
Monoisotopic Mass	313.071 Da
Topological Polar Surface Area	132.000 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	405.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	3

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions, always use the batch-specific molecular weight of the product found on the vial label and the Certificate of Analysis (available online).

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator enables you to quickly determine the volume of a reagent needed to reconstitute your vial. Just enter the mass of the reagent and the target concentration, and the calculator will do the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.