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SAH-SOS1A TFA - 99%, high purity , CAS No.S659123

COA

Grade & Purity:

≥99%

Molecular Weight: 2301.55

In stock

Item Number

S659123

Grouped product items
SKU	Size	Availability	Price	Qty
S659123-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$420.90
S659123-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$700.90

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GPCR/G Protein (3172) Ras (143)

Basic Description

Specifications & Purity	≥99%
Storage Temp	Protected from light,Argon charged,Desiccated,Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA directly and independently blocks nuc Appearance:Solid IC50& Target:KRAS-SOS1 KRas G12C 140 nM (EC 50 ) KRas G12D 109 nM (EC 50 ) KRas G12V 154 nM (EC 50 ) KRas G12S 155 nM (EC 50 ) KRas Q61H 175 nM (EC 50 ) K-Ras WT 106 nM (EC 50 ) In Vitro:SAH-SOS1A TFA (0.625-40 μM; 24 hours) dose-responsively impairs the viability of cancer cells bearing G12D, G12C, G12V, G12S, G13D, and Q61H mutations with IC50 values in the 5- to 15-μM range. Cancer cells expressing wild-type KRAS, such as HeLa and Colo In Vivo:SAH-SOS1A (0.2 μL of 10 mM solution; injection; 48 hours; abdomens of D. melanogaster Ras85D V12 /ActinGS) treatment notably decreases the phosphorylation state of ERK1/2. MCE has not independently confirmed the accuracy of these methods. They are fo Biological Activity:SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA directly and independently blocks nuc

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SAH-SOS1A TFA - 99%, high purity , CAS No.S659123

Basic Description

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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