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RRD-251 hydrochloride - 95%, high purity , CAS No.72214-67-6

COA

Grade & Purity:

≥98%

Cas Number: 72214-67-6
Molecular Weight: 271.59
PubChem CID: 12526767

In stock

Item Number

R338914

Grouped product items
SKU	Size	Availability	Price
R338914-5mg	5mg	1	$49.90
R338914-10mg	10mg	1	$89.90
R338914-25mg	25mg	1	$197.90
R338914-50mg	50mg	1	$316.90
R338914-100mg	100mg	1	$499.90

a reversible selective disruptor of Rb/Raf-1 interaction

View related series

Apoptosis (4276) MAPK/ERK Pathway (546) Raf (69)

Basic Description

Synonyms	2,4-dichlorobenzyl imidothiocarbamate hydrochloride \| (2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride \| 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride \| Rb/Raf-1 disruptor 251 hydrochloride \| S-(2,4-Dichlorobenzyl)-isothiouron
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Halobenzenes
      - Level5 Chlorobenzenes
        Level6 Dichlorobenzenes

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Halobenzenes
Intermediate Tree Nodes	Chlorobenzenes
Direct Parent	Dichlorobenzenes
Alternative Parents	Aryl chlorides Isothioureas Sulfenyl compounds Carboximidamides Organochlorides Imines Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	1,3-dichlorobenzene - Aryl halide - Aryl chloride - Isothiourea - Sulfenyl compound - Carboximidamide - Organic nitrogen compound - Hydrocarbon derivative - Hydrochloride - Organosulfur compound - Organonitrogen compound - Organochloride - Organohalogen compound - Imine - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(2,4-dichlorophenyl)methyl carbamimidothioate;hydrochloride
INCHI	InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChIKey	COMNQRICZGJVLE-UHFFFAOYSA-N
Smiles	C1=CC(=C(C=C1Cl)Cl)CSC(=N)N.Cl
Isomeric SMILES	C1=CC(=C(C=C1Cl)Cl)CSC(=N)N.Cl
PubChem CID	12526767
Molecular Weight	271.59

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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10 results found

Lot Number	Certificate Type	Date	Item
K2427646	Certificate of Analysis	Jul 24, 2024	R338914
K2427647	Certificate of Analysis	Jul 24, 2024	R338914
K2427648	Certificate of Analysis	Jul 24, 2024	R338914
K2427649	Certificate of Analysis	Jul 24, 2024	R338914
K2427650	Certificate of Analysis	Jul 24, 2024	R338914
K2427651	Certificate of Analysis	Jul 24, 2024	R338914
K2427658	Certificate of Analysis	Jul 24, 2024	R338914
K2427659	Certificate of Analysis	Jul 24, 2024	R338914
K2427644	Certificate of Analysis	Jul 24, 2024	R338914
K2427645	Certificate of Analysis	Jul 24, 2024	R338914

Chemical and Physical Properties

Solubility	Soluble in DMSO: >10 mg/mL and Water: >2 mg/mL
Sensitivity	Moisture sensitive
Molecular Weight	271.600 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	269.955 Da
Monoisotopic Mass	269.955 Da
Topological Polar Surface Area	75.200 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	189.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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