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Retatrutide - 99%, high purity , CAS No.2381089-83-2

COA

Grade & Purity:

≥99%

Cas Number: 2381089-83-2
Molecular Weight: 4731.33

In stock

Item Number

R647506

Grouped product items
SKU	Size	Availability	Price
R647506-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
R647506-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$750.90
R647506-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,200.90

View related series

Class B GPCR (170) GCGR (64) GLP Receptor (14) GPCR/G Protein (3172)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Retatrutide (LY3437943) is a triple agonist peptide of the Glukagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and Glukagon-like peptide-1 receptor (GLP-1R) . Retatrutide inhibits human GCGR , GIPR, and GLP-1R with EC 50
Storage Temp	Protected from light,Argon charged,Desiccated,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Retatrutide (LY3437943) is a triple agonist peptide of the Glukagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and Glukagon-like peptide-1 receptor (GLP-1R) . Retatrutide inhibits human GCGR , GIPR, and GLP-1R with EC 50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide can be used for the research of obesity In Vitro Retatrutide (LY3437943) has efficacy for human GCGR, GIPR, and GLP-1R with EC 50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide has efficacy for mouse GCGR, GIPR, and GLP-1R with EC 50 values of 2.32, 0.191 and 0.794 nM, respectively. Retatrutide has binding affinity for human GCGR, GIPR, and GLP-1R with K i values of 5.6, 0.057 and 7.2 nM, respectively. Retatrutide has binding affinity for mouse GCGR, GIPR, and GLP-1R with K i values of 73, 2.8 and 1.3 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Retatrutide (LY3437943) (s.c.; 0.47 mg/kg; single) engages GCGR in vivo and can improve glucose tolerance in an ipGTT through either the GIP or GLP-1 receptors . Retatrutide (s.c.; 10 mL/kg; cycle every 3 days; for 21 days) causes great body weight loss and increases energy expenditure through Glukagon receptor activatio . Retatrutide has safety and tolerability . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD-1 mice Dosage: 0.47 mg/kg Administration: Subcutaneous administration, single Result: AUC last , ngh/mL AUC 0-∞ , ngh/mL C max , ng/mL T max , h t 1/2 , h CLF, mL/h/kg 41135 41905 1680 12 21 11.22 Animal Model: Diet-induced obese (DIO) male C57/Bl6 mice (24-25 weeks, 40-51 g) Dosage: 10 mL/kg Administration: Subcutaneous (SC) injection, cycle every 3 days, for 21 days Result: Decreased body weight and improved glycemic control. Form:Solid IC50& Target:EC50 (for human): 5.79 (GCGR), 0.0643 (GIPR), 0.775 nM (GLP-1R),EC50 (for mouse): 2.32 (GCGR), 0.191 (GIPR), 0.794 nM (GLP-1R),Ki (for human): 5.6 (GCGR), 0.057 (GIPR), 7.2 nM (GLP-1R),Ki (for mouse): 73 (GCGR), 2.8 (GIPR), 1.3 nM (GLP-1R)

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	H2O : 33.33 mg/mL (7.04 mM; ultrasonic and adjust pH to 7 with NaOH)

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