Articles du produit groupé

SKU

Taille

Disponibilité

Prix

Qté

Ab091629-10μl

10μl

69,90$US

Ab091629-50μl

50μl

199,90$US

Ab091629-100μl

100μl

Available within 8-12 weeks(?)

309,90$US

Ab091629-1ml

1ml

Available within 8-12 weeks(?)

1 499,90$US

Description générale

Product Name	Recombinant BRCA1 Antibody - Primary antibody, specific to BRCA1, Mouse IgG1
Synonymes	BRCA 1 antibody \| BRCA1 antibody \| BRCA1 DNA repair associated antibody \| BRCA1/BRCA2 containing complex subunit 1 antibody \| BRCA1/BRCA2-containing complex, subunit 1 antibody \| BRCA1_HUMAN antibody \| BRCAI antibody \| BRCC 1 antibody \| BRCC1 antibody \| B
Spécifications et pureté	ExactAb™, Validated, Recombinant, 4.8 mg/mL
Espèces hôtes	Mouse
Spécificité	BRCA1
Contrôle positif	IHC: Human breast tissue.
Conjugaison	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Mouse anti Human BRCA1 Antibody, Recombinant (MyM1-BRCA-1), could be used for IHC and so on. Application IHC: 1/100-1/200 Protein Function E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.

Propriétés du produit

Isotype	Mouse IgG1
Type de chaîne lumineuse	kappa
SDS-PAGE	150 kDa
Méthode de purification	Protein A purified
Forme	Liquid
Concentration	4.8 mg/mL
Température de stockage	Store at 2-8°C,Avoid repeated freezing and thawing
Expédié en	Wet ice
Stabilité et stockage	Store at 2-8°C long term (36 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Cibles associées (humaines)

BRCA1 Tchem Breast cancer type 1 susceptibility protein (0 Activities)

Discover Target: BRCA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mécanismes d'action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	Références

Images

IHC: Recombinant BRCA1 Antibody (Ab091629) 

Recombinant BRCA1 Antibody (Ab091629) - IHC
Immunohistochemistry analysis of paraffin-embedded human breast tissue labelling BRCA1 with Recombinant BRCA1 Antibody (Ab091629) at 1/100 dilution. The section was incubated with Ab091629 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.

Application

Application	Dilution info
IHC	1/100 - 1/200

Certificats (CoA, COO, BSE/TSE et tableau d'analyse)

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Analytical Chart:

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2 results found

Lot Number	Certificate Type	Date	Article
ZJ24F0505164	Certificate of Analysis	May 07, 2024	Ab091629
ZJ24F0505163	Certificate of Analysis	May 07, 2024	Ab091629

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Recombinant BRCA1 Antibody - Primary antibody, specific to BRCA1, Mouse IgG1

Description générale

Propriétés du produit

Cibles associées (humaines)

Mécanismes d'action

Images

Application

Certificats (CoA, COO, BSE/TSE et tableau d'analyse)

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Molarity Calculator

Dilution Calculator

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Avis des clients

Recombinant BRCA1 Antibody - Primary antibody, specific to BRCA1, Mouse IgG1

Description générale

Propriétés du produit

Cibles associées (humaines)

Mécanismes d'action

Images

Application

Certificats (CoA, COO, BSE/TSE et tableau d'analyse)

Produits apparentés

Calculateurs de solution

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Avis

Avis des clients