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RE 201 - 98%, high purity , Type-1 angiotensin II receptor antagonist, CAS No.254740-64-2, Type-1 angiotensin II receptor antagonist

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 254740-64-2
Molecular Weight: 592.75
PubChem CID: 10257882
PubChem SID: 504765358

In stock

Item Number

R340645

Grouped product items
SKU	Size	Availability	Price
R340645-25mg	25mg	3	$489.90
R340645-50mg	50mg	2	$815.90
R340645-100mg	100mg	2	$1,360.90
R340645-250mg	250mg	2	$3,062.90

View related series

Angiotensin Receptor (92) AT1 receptor Antagonist (33) Class A GPCR (4138) Endothelin Receptor (32) ETA receptor Antagonist (21) GPCR/G Protein (3172)

Basic Description

Synonyms	retrophin \| BDBM50175523 \| GN \| Sparsentan [USAN] \| sparsentanum \| compound 7 (PMID 15634011) \| esparsentan \| IDI1_007881 \| Sparsentan (USAN/INN) \| AC-35179 \| BCP23969 \| EX-A3048 \| Sparsentan(PS433540) \| F77045 \| Q27088845 \| 9242RO5URM \| AKOS040758741 \| s
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Type-1 angiotensin II receptor antagonist

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Biphenyls and derivatives

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Biphenyls and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Biphenyls and derivatives
Alternative Parents	Alpha amino acids and derivatives Benzenesulfonamides Benzenesulfonyl compounds Benzylethers Organosulfonamides Imidazolinones Imidolactams Heteroaromatic compounds Aminosulfonyl compounds Isoxazoles Dialkyl ethers Carboximidamides Carboxamidines Propargyl-type 1,3-dipolar organic compounds Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Carbonyl compounds Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Biphenyl - Alpha-amino acid or derivatives - Benzenesulfonamide - Benzenesulfonyl group - Benzylether - Imidazolinone - Imidolactam - Organosulfonic acid amide - Azole - Heteroaromatic compound - 2-imidazoline - Isoxazole - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Amidine - Oxacycle - Carboxylic acid amidine - Carboxylic acid derivative - Dialkyl ether - Ether - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Hydrocarbon derivative - Organic nitrogen compound - Carbonyl group - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Organic oxygen compound - Organic oxide - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	5

Associated Targets(Human)

AGTR1 Tclin Type-1 angiotensin II receptor (3 Activities)

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EDNRA Tclin Endothelin-1 receptor (3 Activities)

Discover Target: EDNRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

Discover Target: AGTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EDNRA Tclin Endothelin receptor ET-A (5008 Activities)

Discover Target: EDNRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agtr1b Angiotensin II receptor (AT-1) type-1 (1480 Activities)

Discover Target: Agtr1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504765358
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504765358
IUPAC Name	2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide
INCHI	InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)
InChIKey	WRFHGDPIDHPWIQ-UHFFFAOYSA-N
Smiles	CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC
Isomeric SMILES	CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC
PubChem CID	10257882
Molecular Weight	592.75

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
K2223532	Certificate of Analysis	Jul 22, 2022	R340645
K2223531	Certificate of Analysis	Jul 22, 2022	R340645
K2223528	Certificate of Analysis	Jul 22, 2022	R340645
K2223533	Certificate of Analysis	Jul 22, 2022	R340645

Chemical and Physical Properties

Molecular Weight	592.800 g/mol
XLogP3	5.000
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	12
Exact Mass	592.272 Da
Monoisotopic Mass	592.272 Da
Topological Polar Surface Area	122.000 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	1060.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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