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Rapamycin - ≥98%(HPLC), high purity , CAS No.53123-88-9

53 Citations COA COA
In stock
Item Number
S115842
Grouped product items
SKU Size
Availability
 Price Qty
S115842-10mg
10mg
9
$15.90
S115842-25mg
25mg
10
$29.90
S115842-50mg
50mg
7
$39.90
S115842-250mg
250mg
10
$119.90
S115842-1g
1g
10
$339.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

mTORC1 complex inhibitor

View related series
Anti-infection (2803) Antibiotic (1629) Apoptosis (4276) Atg and Atg-related Protein (135) Autophagy (1917) Bacterial (3013) Cell signal transduction and Neuroscience (85) Endogenous Metabolite (959) FKBP (35) Fungal (844) Immunology/Inflammation (1929) Intrinsic Pathway (690) Metabolic Enzyme/Protease (4860) Metabolite (5307) mTOR (145) Pharmaceutical ingredients (367) PI3K/Akt/mTOR (765) Unfolded Protein Response (214)

Basic Description

Synonyms AY 22989 | AY-22989 | CHEBI:9168 | EC 610-965-5 | HMS2089A21 | RAPA | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl
Specifications & Purity Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has antica
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Rapamycin is an anti-fungal antibiotic isolated from Streptomyces hygroscopicus. This antibiotic is active against all strains of Candida albicans. It blocks the signal transduction pathways required for the activation of T-helper cells.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Phenylpropanoids and polyketides
Class Macrolide lactams
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Macrolide lactams
Alternative Parents Alpha amino acid esters  Macrolides and analogues  Cyclohexanols  Piperidines  Oxanes  Tertiary carboxylic acid amides  Carboxylic acid esters  Cyclic alcohols and derivatives  Cyclic ketones  Hemiacetals  Lactams  Lactones  Azacyclic compounds  Dialkyl ethers  Oxacyclic compounds  Monocarboxylic acids and derivatives  Hydrocarbon derivatives  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  
Molecular Framework Aliphatic heteropolycyclic compounds
Substituents Macrolide lactam - Alpha-amino acid ester - Macrolide - Alpha-amino acid or derivatives - Cyclohexanol - Oxane - Piperidine - Cyclic alcohol - Tertiary carboxylic acid amide - Cyclic ketone - Secondary alcohol - Carboxamide group - Carboxylic acid ester - Hemiacetal - Ketone - Lactam - Lactone - Organoheterocyclic compound - Azacycle - Carboxylic acid derivative - Oxacycle - Dialkyl ether - Ether - Monocarboxylic acid or derivatives - Organopnictogen compound - Alcohol - Organic oxygen compound - Carbonyl group - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Aliphatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as macrolide lactams. These are cyclic polyketides containing both a cyclic amide and a cyclic ester group.
External Descriptors Plyenes

Associated Targets(Human)

FKBP1A Tclin Peptidyl-prolyl cis-trans isomerase FKBP1A (10 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
FKBP1B Tchem Peptidyl-prolyl cis-trans isomerase FKBP1B (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
FKBP5 Tchem Peptidyl-prolyl cis-trans isomerase FKBP5 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
EIF4E Tchem Eukaryotic translation initiation factor 4E (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
PDCD4 Tchem Programmed cell death protein 4 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
MTOR Tclin Serine/threonine-protein kinase mTOR (7 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid 488195295
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195295
IUPAC Name (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
INCHI InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChIKey QFJCIRLUMZQUOT-HPLJOQBZSA-N
Smiles CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
Isomeric SMILES C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
RTECS VE6250000
Molecular Weight 914.19
Reaxy-Rn 5848501

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

46 results found

Lot Number Certificate Type Date Item
G2326284 Certificate of Analysis Apr 18, 2025 S115842
G2326288 Certificate of Analysis Apr 18, 2025 S115842
G2326291 Certificate of Analysis Apr 08, 2025 S115842
G2326272 Certificate of Analysis Apr 08, 2025 S115842
C2505453 Certificate of Analysis Feb 25, 2025 S115842
C2505454 Certificate of Analysis Feb 25, 2025 S115842
C2505456 Certificate of Analysis Feb 25, 2025 S115842
C2505457 Certificate of Analysis Feb 25, 2025 S115842
C2505458 Certificate of Analysis Feb 25, 2025 S115842
E2305215 Certificate of Analysis Feb 11, 2025 S115842
E2305205 Certificate of Analysis Feb 11, 2025 S115842
E2305213 Certificate of Analysis Feb 11, 2025 S115842
E2305219 Certificate of Analysis Feb 11, 2025 S115842
E2305216 Certificate of Analysis Feb 11, 2025 S115842
K2228737 Certificate of Analysis Sep 04, 2024 S115842
H2428319 Certificate of Analysis Jul 24, 2024 S115842
H2428320 Certificate of Analysis Jul 24, 2024 S115842
H2428322 Certificate of Analysis Jul 24, 2024 S115842
H2428321 Certificate of Analysis Jul 24, 2024 S115842
H2428300 Certificate of Analysis Jul 24, 2024 S115842
E2421160 Certificate of Analysis Apr 10, 2024 S115842
E2421161 Certificate of Analysis Apr 10, 2024 S115842
E2421162 Certificate of Analysis Apr 10, 2024 S115842
E2421163 Certificate of Analysis Apr 10, 2024 S115842
E2421478 Certificate of Analysis Apr 10, 2024 S115842
B2518461 Certificate of Analysis Mar 29, 2024 S115842
B2518477 Certificate of Analysis Mar 29, 2024 S115842
B2518504 Certificate of Analysis Mar 29, 2024 S115842
G2326282 Certificate of Analysis Jul 08, 2023 S115842
E2305217 Certificate of Analysis Feb 22, 2023 S115842
E2305104 Certificate of Analysis Feb 22, 2023 S115842
E2305193 Certificate of Analysis Feb 22, 2023 S115842
E2305202 Certificate of Analysis Feb 22, 2023 S115842
E2305212 Certificate of Analysis Feb 22, 2023 S115842
K2228734 Certificate of Analysis Oct 14, 2022 S115842
K2228735 Certificate of Analysis Oct 14, 2022 S115842
K2228736 Certificate of Analysis Oct 14, 2022 S115842
K2228738 Certificate of Analysis Oct 14, 2022 S115842
H2230023 Certificate of Analysis Sep 03, 2022 S115842
G2227353 Certificate of Analysis Jun 11, 2022 S115842
K2218143 Certificate of Analysis Jun 11, 2022 S115842
G2227352 Certificate of Analysis Jun 11, 2022 S115842
G2227354 Certificate of Analysis Jun 11, 2022 S115842
G2227355 Certificate of Analysis Jun 11, 2022 S115842
J2215165 Certificate of Analysis Jun 11, 2022 S115842
D2009140 Certificate of Analysis Feb 17, 2022 S115842

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Chemical and Physical Properties

Solubility Insoluble in water; Soluble in Chloroform,Acetone,Dimethylformamide,Methanol,Ether
Sensitivity Heat sensitive.
Specific Rotation[α] -150° (C=0.2,MeOH)
Melt Point(°C) 177 °C(dec.)
Molecular Weight 914.200 g/mol
XLogP3 6.000
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 13
Rotatable Bond Count 6
Exact Mass 913.555 Da
Monoisotopic Mass 913.555 Da
Topological Polar Surface Area 195.000 Ų
Heavy Atom Count 65
Formal Charge 0
Complexity 1760.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 15
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 4
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 4
Covalently-Bonded Unit Count 1

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