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PZ-II-029 - ≥98%(HPLC), high purity , CAS No.164025-44-9, Allosteric modulator of GABA A receptor α6 subunit

COA

Grade & Purity:

Moligand™

≥98%(HPLC)

Cas Number: 164025-44-9
Molecular Weight: 321.33
EC Number: 803-192-1
PubChem CID: 10426200
PubChem SID: 504765458

In stock

Item Number

P287515

Grouped product items
SKU	Size	Availability	Price
P287515-5mg	5mg	3	$58.90
P287515-10mg	10mg	3	$106.90
P287515-25mg	25mg	3	$228.90
P287515-50mg	50mg	3	$410.90
P287515-100mg	100mg	3	$738.90

α6β3γ2-selective GABAApositive allosteric modulator

View related series

GABAA receptor α6 subunit Allosteric modulator (11) Ion channel (2197)

Basic Description

Synonyms	BDBM85038 \| AKOS032962877 \| compound 6 [PMID: 23472852] \| PZ II029 \| PZ II-029 \| 7-methoxy-2-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one \| GTPL12403 \| PZII029 \| PZ-II029 \| PZ-II-029 \| PZII-029 \| 7-methoxy-2-(4-methoxyphenyl)-2,5-dihydro-3h-pyrazolo
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	GABAApositive allosteric modulator. Selectively binds with high affinity to α6β3γ2 subunit-containing channels. Inhibits central and peripheral trigeminal responses in a rat migraine model.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of GABA A receptor α6 subunit

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Azoles
    - Subclass Pyrazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Azoles
Subclass	Pyrazoles
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyrazoles
Alternative Parents	Quinolines and derivatives Methoxyanilines Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers Pyridines and derivatives Pyrazolones Vinylogous amides Heteroaromatic compounds Lactams Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenylpyrazole - Quinoline - Methoxyaniline - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - Monocyclic benzene moiety - Pyrazolinone - Pyridine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Lactam - Ether - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

GABRA6 Tclin Gamma-aminobutyric acid receptor subunit alpha-6 (0 Activities)

Discover Target: GABRA6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	504765458
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504765458
IUPAC Name	7-methoxy-2-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one
INCHI	InChI=1S/C18H15N3O3/c1-23-12-5-3-11(4-6-12)21-18(22)15-10-19-16-9-13(24-2)7-8-14(16)17(15)20-21/h3-10,20H,1-2H3
InChIKey	CGOOCGJMECBDCB-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)N2C(=O)C3=CN=C4C=C(C=CC4=C3N2)OC
Isomeric SMILES	COC1=CC=C(C=C1)N2C(=O)C3=CN=C4C=C(C=CC4=C3N2)OC
WGK Germany	3
Alternate CAS	164025-44-9
PubChem CID	10426200
UN Number	3077
Packing Group	III
MeSH Entry Terms	7-methoxy-2-(4-methoxyphenyl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one;pyrazoloquinolinone compound 6;PZ-II-029
Molecular Weight	321.33

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
G2206421	Certificate of Analysis	Apr 07, 2025	P287515
G2206422	Certificate of Analysis	Apr 07, 2025	P287515
G2206418	Certificate of Analysis	Apr 07, 2025	P287515
G2206419	Certificate of Analysis	Apr 07, 2025	P287515
G2206420	Certificate of Analysis	Apr 07, 2025	P287515

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 32.13, Max Conc. mM: 100；DMSO: 10 mg/mL, clear
Molecular Weight	321.300 g/mol
XLogP3	3.100
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	321.111 Da
Monoisotopic Mass	321.111 Da
Topological Polar Surface Area	63.700 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	466.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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