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PX-478 2HCl - 98%, high purity , CAS No.685898-44-6

COA COA
In stock
Item Number
P413792
Grouped product items
SKU Size
Availability
 Price Qty
P413792-5mg
5mg
2
$86.90
P413792-10mg
10mg
2
$129.90
P413792-25mg
25mg
2
$199.90
P413792-50mg
50mg
2
$369.90
P413792-100mg
100mg
2
$699.90
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HIF Inhibitors

View related series
Autophagy (1917) Glucose Metabolism (1943) HIF/HIF Prolyl-Hydroxylase (128) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms A867013 | PX 478 [WHO-DD] | Q27289565 | s7612 | CCG-268582 | PX 478 | AKOS030231369 | AS-76128 | DTXSID00218688 | SCHEMBL18548830 | AC2217 | BDBM50231387 | L-Phenylalanine, 4-(bis(2-chloroethyl)oxidoamino)-, dihydrochloride | A14319 | PX478 | PX-478 | HY-
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.
Storage Temp Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Product Description

Information

PX-478 2HCl PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.


Targets

HIF-1α


In vitro

PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells.


In vivo

In HT-29 human colon cancer xenografts, PX-478 suppresses HIF-1alpha levels and inhibits the expression of HIF-1 target genes including vascular endothelial growth factor and the glucose transporter-1. In addition, PX-478 (100 or 120 mg/kg i.p.) also shows antitumor activity including cures against several established human tumor xenografts that is related to the levels of HIF-1α. In high-fat-diet mice, PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organic acids and derivatives
Class Carboxylic acids and derivatives
Subclass Amino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct Parent Phenylalanine and derivatives
Alternative Parents Phenylpropanoic acids  Amphetamines and derivatives  L-alpha-amino acids  Nitrogen mustard compounds  Aralkylamines  Amino acids  Trisubstituted amine oxides and derivatives  Monocarboxylic acids and derivatives  Carboxylic acids  Hydrochlorides  Hydrocarbon derivatives  Monoalkylamines  Carbonyl compounds  Organic oxides  Organic zwitterions  Organochlorides  Alkyl chlorides  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Phenylalanine or derivatives - 3-phenylpropanoic-acid - Alpha-amino acid - Amphetamine or derivatives - L-alpha-amino acid - Nitrogen mustard - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Amino acid - N-oxide - Carboxylic acid - Monocarboxylic acid or derivatives - Trisubstituted n-oxide - Alkyl chloride - Primary amine - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic zwitterion - Organic salt - Primary aliphatic amine - Hydrochloride - Carbonyl group - Hydrocarbon derivative - Organic oxide - Amine - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as phenylalanine and derivatives. These are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors Not available

Product Properties

ALogP -0.251
HBD Count 1
Rotatable Bond 8

Associated Targets(Human)

MCF7 (126967 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-468 (9477 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488197315
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488197315
IUPAC Name 4-[(2S)-2-amino-2-carboxyethyl]-N,N-bis(2-chloroethyl)benzeneamine oxide;dihydrochloride
INCHI InChI=1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1
InChIKey GIGCDIVNDFQKRA-LTCKWSDVSA-N
Smiles C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
Isomeric SMILES C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
PubChem CID 11234794
Molecular Weight 394.12

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
B23271059 Certificate of Analysis Aug 12, 2022 P413792
B23271060 Certificate of Analysis Aug 12, 2022 P413792
B23271010 Certificate of Analysis Aug 12, 2022 P413792
B23271051 Certificate of Analysis Aug 12, 2022 P413792
B23271052 Certificate of Analysis Aug 12, 2022 P413792
B23271061 Certificate of Analysis Aug 12, 2022 P413792
B2327973 Certificate of Analysis Aug 12, 2022 P413792
B2327943 Certificate of Analysis Aug 12, 2022 P413792
B2327988 Certificate of Analysis Aug 12, 2022 P413792
B2327941 Certificate of Analysis Aug 12, 2022 P413792

Chemical and Physical Properties

Solubility Solubility (25°C) In vitro DMSO: 79 mg/mL (200.44 mM); Water: 79 mg/mL (200.44 mM); Ethanol: 20 mg/mL (50.74 mM);
Sensitivity Moisture sensitive
DMSO(mg / mL) Max Solubility 78
DMSO(mM) Max Solubility 197.9092662
Water(mg / mL) Max Solubility 78
Water(mM) Max Solubility 197.9092662
Molecular Weight 394.100 g/mol
XLogP3
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 8
Exact Mass 394.02 Da
Monoisotopic Mass 392.023 Da
Topological Polar Surface Area 81.400 Ų
Heavy Atom Count 22
Formal Charge 0
Complexity 304.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 3

Alternative Products

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    PX-478 2HCl
    • 10mM in DMSO

    Starting at $74.90

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