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Pumosetrag Hydrochloride - 10mM in DMSO, high purity , CAS No.194093-42-0(DMSO), Serotonin 3 (5-HT3) receptor partial agonist

COA

Grade & Purity:

10mM in DMSO

Cas Number: 194093-42-0(DMSO)
Molecular Weight: 339.84

In stock

Item Number

P655825

Grouped product items
SKU	Size	Availability	Price	Qty
P655825-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$132.90

View related series

5-HT Receptor (264) Compound libraries (12325) GPCR/G Protein (3172) Neuronal Signaling (3320)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.
Storage Temp	Desiccated,Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Action Type	PARTIAL AGONIST
Mechanism of action	Serotonin 3 (5-HT3) receptor partial agonist
Product Description	Pumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. In Vivo Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors . Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:5-HT 3 Receptor

Associated Targets(Human)

HTR3A Tclin 5-hydroxytryptamine receptor 3A (2 Activities)

Discover Target: HTR3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Smiles	C1CN2CCC1C(C2)NC(=O)C3=CNC4=C(C3=O)SC=C4.Cl
Molecular Weight	339.84

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

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