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Procaine hydrochloride - 99%, high purity , CAS No.51-05-8

8 Citations COA COA
In stock
Item Number
P113899
Grouped product items
SKU Size
Availability
 Price Qty
P113899-5g
5g
2
$9.90
P113899-25g
25g
8
$19.90
P113899-100g
100g
4
$49.90
P113899-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$199.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Na + channel blocker. DNA methylation inhibitor.

View related series
Bacterial (3013) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) DNA/RNA Synthesis (362) Epigenetics (1496) Histone Demethylase (97) Histone Modification (1379)

Basic Description

Synonyms Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride | Cetain | HY-B0546A | EINECS 200-077-2 | Enpro | HMS1568I03 | Novocain | PROCAINE HYDROCHLORIDE [USP MONOGRAPH] | Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester, monohydrochlorid
Specifications & Purity Moligand™, ≥99%
Biochemical and Physiological Mechanisms Procaine is a Na+ channel blocker, commonly used as an anesthetic agent and is considered safer than cocaine.It is also useful as a painkiller to treat pain, associated with joints and tendons
Storage Temp Argon charged
Shipped In Normal
Grade Moligand™
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Procaine is an inhibitor of sodium channel, NMDA receptor and nAChR with IC50 of 60 μM, 0.296 mM and 45.5 μM, which is also an inhibitor of 5-HT3 with KD of 1.7 μM.
A sodium channel blocker and DNA methylation inhibitor

Application：

Procaine hydrochloride has been used as a component of Krebs Henseleit buffer for incubating the left ventricular cardiac tissue in its resting length. It has also been used as an inducer in M9 media for induction assay.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzoic acids and derivatives
Intermediate Tree Nodes Not available
Direct Parent Benzoic acid esters
Alternative Parents Aminobenzoic acids and derivatives  Benzoyl derivatives  Aniline and substituted anilines  Trialkylamines  Carboxylic acid esters  Amino acids and derivatives  Monocarboxylic acids and derivatives  Primary amines  Organopnictogen compounds  Organooxygen compounds  Organic oxides  Hydrochlorides  Hydrocarbon derivatives  
Molecular Framework Aromatic homomonocyclic compounds
Substituents Aminobenzoic acid or derivatives - Benzoate ester - Benzoyl - Aniline or substituted anilines - Carboxylic acid ester - Amino acid or derivatives - Tertiary amine - Tertiary aliphatic amine - Carboxylic acid derivative - Monocarboxylic acid or derivatives - Organooxygen compound - Organonitrogen compound - Organic oxide - Hydrocarbon derivative - Organopnictogen compound - Amine - Organic oxygen compound - Organic nitrogen compound - Primary amine - Hydrochloride - Aromatic homomonocyclic compound
Description This compound belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid.
External Descriptors organic molecular entity

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Oryctolagus cuniculus (11301 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Npsr1 Neuropeptide S receptor (260 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Hsf1 Heat shock factor protein 1 (5445 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
nfo Endonuclease 4 (425 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488179937
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488179937
IUPAC Name 2-(diethylamino)ethyl 4-aminobenzoate;hydrochloride
INCHI InChI=1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H
InChIKey HCBIBCJNVBAKAB-UHFFFAOYSA-N
Smiles CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl
Isomeric SMILES CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.Cl
WGK Germany 3
RTECS DG2275000
UN Number 2811
Molecular Weight 272.77
Beilstein 3917802
Reaxy-Rn 3917802
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3917802&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot Number Certificate Type Date Item
E2128503 Certificate of Analysis Mar 04, 2025 P113899
A2503476 Certificate of Analysis Dec 18, 2024 P113899
A2503477 Certificate of Analysis Dec 18, 2024 P113899
A2503478 Certificate of Analysis Dec 18, 2024 P113899
A2503652 Certificate of Analysis Dec 18, 2024 P113899
I2418045 Certificate of Analysis Jul 09, 2024 P113899
G2418414 Certificate of Analysis Jul 09, 2024 P113899
G2418415 Certificate of Analysis Jul 09, 2024 P113899
G2418433 Certificate of Analysis Jul 09, 2024 P113899
G2418434 Certificate of Analysis Jul 09, 2024 P113899
G2418450 Certificate of Analysis Jul 09, 2024 P113899
L1909160 Certificate of Analysis Sep 08, 2023 P113899
C2425075 Certificate of Analysis Dec 16, 2021 P113899
B2310333 Certificate of Analysis Dec 16, 2021 P113899
J2331112 Certificate of Analysis Dec 16, 2021 P113899
F2307350 Certificate of Analysis Dec 16, 2021 P113899
E2128504 Certificate of Analysis Jun 07, 2021 P113899
B2310334 Certificate of Analysis Apr 09, 2021 P113899
D2324753 Certificate of Analysis Apr 09, 2021 P113899

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Chemical and Physical Properties

Solubility Soluble in ethanol, slightly soluble in chloroform, insoluble in ether
Sensitivity Light and Air sensitive
Melt Point(°C) 155-156°C
Molecular Weight 272.770 g/mol
XLogP3
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 4
Rotatable Bond Count 7
Exact Mass 272.129 Da
Monoisotopic Mass 272.129 Da
Topological Polar Surface Area 55.600 Ų
Heavy Atom Count 18
Formal Charge 0
Complexity 221.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 2

Alternative Products

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Solution Calculators

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