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PFK15 , CAS No.P612764, Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

COA COA
In stock
Item Number
P612764
Grouped product items
SKU Size
Availability
 Price Qty
P612764-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
P612764-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,001.90
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6-phosphofructo-2-kinase/fructose-2，6-biphosphatase 3 Inhibitor (3)

Basic Description

Synonyms PFK015 | PFK-015 | 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one | PFK 015 | SCHEMBL2702934 | HY-12204 | EN300-22345725 | PFK 15 | HSDB 3055 | AKOS025287166 | NCGC00386328-09 | C75180 | EX-A4218 | 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one | SW21
Specifications & Purity Moligand™
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of 6-phosphofructo-2-kinase/fructose-2;6-biphosphatase 3

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Quinolines and derivatives
Subclass Not available
Intermediate Tree Nodes Not available
Direct Parent Quinolines and derivatives
Alternative Parents Aryl ketones  Pyridines and derivatives  Benzenoids  Heteroaromatic compounds  Enones  Acryloyl compounds  Azacyclic compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Quinoline - Aryl ketone - Pyridine - Benzenoid - Acryloyl-group - Enone - Alpha,beta-unsaturated ketone - Heteroaromatic compound - Ketone - Azacycle - Organic oxide - Organic oxygen compound - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
External Descriptors Not available

Associated Targets(Human)

PFKFB3 Tchem 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PFKFB3 Tchem 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (1469 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

IUPAC Name 1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one
INCHI InChI=1S/C17H12N2O/c20-17(14-9-11-18-12-10-14)8-7-15-6-5-13-3-1-2-4-16(13)19-15/h1-12H
InChIKey UJJUKZPBUMCSJZ-UHFFFAOYSA-N
Smiles O=C(c1ccncc1)C=Cc1ccc2c(n1)cccc2
Isomeric SMILES C1=CC=C2C(=C1)C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3
PubChem CID 25142799

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Chemical and Physical Properties

Molecular Weight 260.290 g/mol
XLogP3 2.900
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 3
Exact Mass 260.095 Da
Monoisotopic Mass 260.095 Da
Topological Polar Surface Area 42.900 Ų
Heavy Atom Count 20
Formal Charge 0
Complexity 360.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 1
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 1
Covalently-Bonded Unit Count 1

Solution Calculators

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