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PF-06471553 - 10mM in DMSO, high purity , CAS No.1808094-07-6(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 1808094-07-6(DMSO)
Molecular Weight: 467.54

In stock

Item Number

P656363

Grouped product items
SKU	Size	Availability	Price	Qty
P656363-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$528.90

View related series

Acyltransferase (66) Compound libraries (12325) Metabolic Enzyme/Protease (4860)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM.
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM. In Vitro PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC 50 , >50 μM), DGAT2 (IC 50 , >100 μM), MGAT1 (IC 50 , 14.9 μM), and MGAT2 (IC 50 , 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC 50 of 205 nM (pIC 50 , 6.69). MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 92 nM (MGAT3)

Associated Targets(Human)

MGAT3 Tchem Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (4 Activities)

Discover Target: MGAT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Smiles	COC1=CC=CC(=C1)CC(=O)N2CC3=C(C2)C=C(C=C3)S(=O)(=O)NC4=NN(N=C4)C5CCC5
Molecular Weight	467.54

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

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