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| SKU | Size | Availability |
Price | Qty |
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P638964-50mg
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50mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$542.90
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PDPH
| Storage Temp | Store at 2-8°C,Desiccated |
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| Shipped In |
Wet ice This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
Product introduction: PDPH is a short, pyridyldithiol-and-hydrazide crosslinker for reversibly conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates). Features of PDPH : • Reactive groups:pyridyldisulfide andhydrazide • Reactive toward: sulfhydryl groups and carbonyl (aldehyde) groups • Short (9.2A), sulfhydryl-to-aldehyde crosslinker with disulfide bond spacer arm (cleavable) • Pyridyldithiol group results in attachment to sulfhydryls via disulfide bond, which can be cleaved with DTT, TCEP or other reducing agents • Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates • Usesodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups • Use withEDC to conjugate primary amine of hydrazide group to carboxyl groups Product References: Crosslinker Application Guide -- search for recent literature references for this product • Reactive Moiety:Hydrazide,Pyridyldisulfide • Crosslinker Type:Heterobifunctional • Form:Powder: • Spacer:Short(<10 Å),Cleavable:By Thiols • Labeling Method:Chemical Labeling • Spacer Arm Length:9.2 Å |
| Reactivity | Carbohydrate-Sulfhydryl |
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| Molecular Weight | 229.32 |
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| Solubility | DMF,DMSO |
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