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Palmatine - analytical standard,≥97%, high purity , CAS No.3486-67-7

16 Citations

COA

Grade & Purity:

analytical standard

Moligand™

≥97%

Cas Number: 3486-67-7
Molecular Weight: 352.4
PubChem CID: 19009

In stock

Item Number

P111383

Grouped product items
SKU	Size	Availability	Price
P111383-20mg	20mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$16.90
P111383-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$21.90
P111383-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$41.90

View related series

Amino Acid/Protein Metabolism (1836) Anti-infection (2803) Apoptosis (4276) Aurora Kinase (63) Bacterial (3013) Cell Cycle (2830) Cell Cycle/DNA Damage (2602) Class A GPCR (4138) Epigenetics (1496) Histone Modification (1379) Indoleamine 2,3-Dioxygenase (IDO) (59) Metabolic Enzyme/Protease (4860) Parasite (997) Virus (1811) Virus Protease (105)

Basic Description

Synonyms	KBio2_007496 \| PALMITINE \| 7,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxyberbinium \| KBio1_001659 \| KBio3_001854 \| Palmatine-chloride \| KBioGR_001469 \| PALMATINE (NEGATIVE MARKER) (CONSTITUENT OF GOLDENSEAL) \| 5-21-06-00202 (Beilstein Handbook Reference) \| K
Specifications & Purity	analytical standard, Moligand™, ≥97%
Storage Temp	Protected from light
Shipped In	Normal
Grade	analytical standard, Moligand™
Product Description	Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Alkaloids and derivatives
  - Class Protoberberine alkaloids and derivatives

Kingdom	Organic compounds
Superclass	Alkaloids and derivatives
Class	Protoberberine alkaloids and derivatives
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Protoberberine alkaloids and derivatives
Alternative Parents	Isoquinolines and derivatives Anisoles Alkyl aryl ethers Pyridinium derivatives Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives Organic cations
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Protoberberine skeleton - Isoquinoline - Anisole - Alkyl aryl ether - Pyridine - Pyridinium - Benzenoid - Heteroaromatic compound - Ether - Organoheterocyclic compound - Azacycle - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic cation - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.
External Descriptors	a small molecule
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
INCHI	InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1
InChIKey	QUCQEUCGKKTEBI-UHFFFAOYSA-N
Smiles	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC
Isomeric SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC
Molecular Weight	352.4
Reaxy-Rn	1555498
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1555498&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
I2212228	Certificate of Analysis	Jun 19, 2024	P111383
I2212233	Certificate of Analysis	Jun 19, 2024	P111383
F2001098	Certificate of Analysis	Dec 20, 2023	P111383
L1514042	Certificate of Analysis	May 08, 2023	P111383

Chemical and Physical Properties

Sensitivity	Light sensitive
Molecular Weight	352.400 g/mol
XLogP3	3.700
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	352.155 Da
Monoisotopic Mass	352.155 Da
Topological Polar Surface Area	40.800 Å²
Heavy Atom Count	26
Formal Charge	1
Complexity	475.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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