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Orphenadrine hydrochloride - 10mM in DMSO, high purity , CAS No.341-69-5, Glutamate [NMDA] receptor antagonist
Cas Number: 341-69-5
Molecular Weight: 305.84
Beilstein Registry Number:
3745818
PubChem CID:
9568
Basic Description
Synonyms
Orphenadrine hydrochloride | 341-69-5 | Orphenadrine HCl | Mephenamin | Disipal | Mebedrol | Mephenamine | Mephenamin forte | Mefenamin hydrochloride | Orphenadrine (hydrochloride) | Mephenamin hydrochloride | Orfenadrin hydrochloride | Mephenamine hydrochloride | Brocadisipal | Orp
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.
Storage Temp
Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Mechanism of action
Glutamate [NMDA] receptor antagonist
Taxonomic Classification
Kingdom
Organic compounds
Superclass
Benzenoids
Class
Benzene and substituted derivatives
Subclass
Diphenylmethanes
Intermediate Tree Nodes
Not available
Direct Parent
Diphenylmethanes
Alternative Parents
Benzylethers Toluenes Trialkylamines Dialkyl ethers Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework
Aromatic homomonocyclic compounds
Substituents
Diphenylmethane - Benzylether - Toluene - Tertiary amine - Tertiary aliphatic amine - Ether - Dialkyl ether - Organopnictogen compound - Amine - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrochloride - Hydrocarbon derivative - Aromatic homomonocyclic compound
Description
This compound belongs to the class of organic compounds known as diphenylmethanes. These are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.
External Descriptors
hydrochloride
Data sources
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
Mechanism of Action
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
References
Names and Identifiers
IUPAC Name
N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine;hydrochloride
INCHI
InChI=1S/C18H23NO.ClH/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;/h4-12,18H,13-14H2,1-3H3;1H
InChIKey
UQZKYYIKWZOKKD-UHFFFAOYSA-N
Smiles
CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.Cl
Isomeric SMILES
CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.Cl
WGK Germany
3
RTECS
KR6300000
UN Number
2811
Packing Group
I
Molecular Weight
305.84
Beilstein
3745818
Reaxy-Rn
3745818
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3745818&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
Melt Point(°C)
160-164°C
Molecular Weight
305.800 g/mol
XLogP3
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
6
Exact Mass
305.155 Da
Monoisotopic Mass
305.155 Da
Topological Polar Surface Area
12.500 Ų
Heavy Atom Count
21
Formal Charge
0
Complexity
260.000
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
The total count of all stereochemical bonds
0
Covalently-Bonded Unit Count
2
Citations of This Product
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1 Citations