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Oprozomib (ONX 0912) - 10mM in DMSO, high purity , CAS No.935888-69-0(DMSO), 26S proteosome inhibitor

COA

Grade & Purity:

Moligand™

10mM in DMSO

Cas Number: 935888-69-0(DMSO)
Molecular Weight: 532.61

In stock

Item Number

O408771

Grouped product items
SKU	Size	Availability	Price	Qty
O408771-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$391.90

20S proteasome Selective Inhibitors

View related series

Compound libraries (12325)

Basic Description

Synonyms	PR-047 \| L-Serinamide, O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-
Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	26S proteosome inhibitor
Product Description	Information Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of20S proteasomeβ5/LMP7 withIC50of 36 nM/82 nM. Phase 1/2. In vitro The anti-MM activity of Oprozomib is associated with activation of caspase-8, caspase-9, caspase-3, and PARP, as well as inhibition of migration of MM cells and angiogenesis. In vivo Oprozomib is demonstrated an absolute bioavailability of up to 39% in rodents and dogs. It is well tolerated with repeated oral administration at doses resulting in >80% proteasome inhibition in most tissues and elicited an antitumor response in multiple human tumor xenograft and mouse syngeneic models . Cell Data cell lines： Concentrations：~1 μM Incubation Time：48 h Powder Purity:≥99%

Associated Targets(Human)

PSMB5 Tclin Proteasome subunit beta type-5 (4 Activities)

Discover Target: PSMB5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PSMB8 Tclin Proteasome subunit beta type-8 (2 Activities)

Discover Target: PSMB8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Smiles	COCC(NC(=O)C(COC)NC(=O)C1=CN=C(C)S1)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(C)CO3
Molecular Weight	532.61

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 28 mg/mL (200.54 mM); Water: 28 mg/mL (200.54 mM); Ethanol: 28 mg/mL (200.54 mM);

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