Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K d values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51 , respectively.
Storage Temp
Protected from light,Store at -80°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Description
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K d values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51 , respectively
In Vitro
Obtusifoliol (0.1-100 µM; 48 hours) inhibit MCF-7 and MDA-MB231 breast cancer cells proliferation via arresting cell cycle progression and induction of apoptosis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7; MDA-MB231 breast cancer cells Concentration: 0.1, 1, 10, 40, 80, and 100 µM Incubation Time: 48 hours Result: Inhibited MCF-7 and MDA-MB231 breast cancer cells proliferation.
This compound belongs to the class of organic compounds known as ergosterols and derivatives. These are steroids containing ergosta-5,7,22-trien-3beta-ol or a derivative thereof, which is based on the 3beta-hydroxylated ergostane skeleton.
External Descriptors
Ergosterols and C24-methyl derivatives
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
