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OAC1 - ≥97%, high purity , CAS No.300586-90-7

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OAC1 - ≥97%, high purity , CAS No.300586-90-7

COA

Grade & Purity:

≥97%

Cas Number: 300586-90-7
Molecular Weight: 237.26
MDL number: MFCD00572806
PubChem CID: 789882

In stock

Item Number

O129631

Grouped product items
SKU	Size	Availability	Price
O129631-5mg	5mg	3	$56.90
O129631-25mg	25mg	3	$235.90
O129631-100mg	100mg	2	$783.90

Oct4 activator; enhances iPSC reprogramming efficiency

View related series

azole (525) DNA Methylation (216) Epigenetics (1496) Five-Membered Heterocyclic Compounds (2064) Oct3/4 (6) Stem Cell/Wnt (1019) TET Protein (9)

Basic Description

Synonyms	OAC-1 \| Oct4-activating Compound 1 \| N-1H-Pyrrolo[2,3-c]pyridin-5-ylbenzamide
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Oct4 activator. Enhances and accelerates iPSC reprogramming in the presence of 4F (Oct4, Sox2, c-Myc and Klf4) by ~20-fold compared to 4F alone. Induces mRNA expression of Oct4, Sox2 and Nanog and also Tet1. Displays no effects on p53-p21 pathway or Wnt-β
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	AC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming. An Oct-4 activator which increases mRNA expression of Oct-4, Sox-2, Nanog, and Tet1

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrrolopyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrrolopyridines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Pyrrolopyridines
Alternative Parents	Benzamides Benzoyl derivatives Pyridines and derivatives Imidolactams Pyrroles Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzamide - Benzoic acid or derivatives - Pyrrolopyridine - Benzoyl - Monocyclic benzene moiety - Pyridine - Benzenoid - Imidolactam - Pyrrole - Heteroaromatic compound - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as pyrrolopyridines. These are compounds containing a pyrrolopyridine moiety, which consists of a pyrrole ring fused to a pyridine. Pyrrole is 5-membered ring consisting of four carbon atoms and one nitrogen atom. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide
INCHI	InChI=1S/C14H11N3O/c18-14(10-4-2-1-3-5-10)17-13-8-11-6-7-15-12(11)9-16-13/h1-9,15H,(H,16,17,18)
InChIKey	HWJRIFZDXJKJJN-UHFFFAOYSA-N
Smiles	C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3
Isomeric SMILES	C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3
WGK Germany	3
Molecular Weight	237.26
Reaxy-Rn	32136747
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32136747&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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1 results found

Lot Number	Certificate Type	Date	Item
D1928143	Certificate of Analysis	Jan 11, 2023	O129631

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 23.73, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 23.73, Max Conc. mM: 100
Sensitivity	Light Sensitive,Air Sensitive,Heat Sensitive
Refractive Index	1.76
Boil Point(°C)	~386.6 °C at 760 mmHg
Melt Point(°C)	197.05°C
Molecular Weight	237.260 g/mol
XLogP3	2.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	237.09 Da
Monoisotopic Mass	237.09 Da
Topological Polar Surface Area	57.800 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	301.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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