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NLRP3/AIM2-IN-3 - 10mM in DMSO, high purity , CAS No.1787787-60-3(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 1787787-60-3(DMSO)
Molecular Weight: 266.29

In stock

Item Number

N656721

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SKU	Size	Availability	Price	Qty
N656721-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$94.90

View related series

AIM2 (7) Apoptosis (4276) Compound libraries (12325) Immunology/Inflammation (1929) NOD-like Receptor (NLR) (55) Pyroptosis (9)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis . NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis . NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC 50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization In Vitro NLRP3/AIM2-IN-3 (0-100 μM) displays remarkable inhibitory activity against NLRP3-and AIM2-but not NLRC4-dependent activation of caspase-1 and the release of IL-1b in human THP-1 macrophages. NLRP3/AIM2-IN-3 shows inhibition of IL-1b secretion by human THP-1 macrophages, with IC 50 of 0.098 μM, which is nearly 150-fold and 500-fold more potent than that of J774A.1 (14.62 μM) and bone marrow-derived macrophages (BMDMs) (48.98 μM), respectively. NLRP3/AIM2-IN-3 has almost no inhibitory effect on the AIM2 inflammasome-dependent activation of caspase-1 and release of IL-1b in J774A.1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:NLRP3

Names and Identifiers

Smiles	O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3
Molecular Weight	266.29

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