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NLG919 - ≥98%, high purity , CAS No.1402836-58-1, Inhibitor of indoleamine 2;3-dioxygenase 1;Inhibitor of tryptophan 2;3-dioxygenase

4 Citations COA COA
In stock
Item Number
N129887
Grouped product items
SKU Size
Availability
 Price Qty
N129887-10mg
10mg
10
$37.90
N129887-50mg
50mg
2
$132.90
N129887-100mg
100mg
1
$211.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

Potent, small molecule IDO pathway inhibitor

View related series
Amino Acid/Protein Metabolism (1836) Indoleamine 2,3-Dioxygenase (IDO) (59) indoleamine 2，3-dioxygenase 1 Inhibitor (13) Metabolic Enzyme/Protease (4860) tryptophan 2，3-dioxygenase Inhibitor (3)

Basic Description

Synonyms HY-13983 | BDBM50126144 | GTPL9019 | NLG919 (GDC-0919) | YTRRAUACYORZLX-UHFFFAOYSA-N | 2-Naphthalenesulfonic acid, 7, {7'-(carbonyldiimino)bis[4-hydroxy-3-(phenylazo)-,} | CCG-267268 | NCGC00386274-04 | SY046802 | SB16495 | 3-(2-Amino-ethyl)-5-[3-(4-butox
Specifications & Purity Moligand™, ≥98%
Biochemical and Physiological Mechanisms NLG919 is a potent indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (K i = 7 nM; EC 50 = 75 nM) in cell-free assays.
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade Moligand™
Action Type INHIBITOR
Mechanism of action Inhibitor of indoleamine 2;3-dioxygenase 1;Inhibitor of tryptophan 2;3-dioxygenase
Product Description

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Isoindoles and derivatives
Subclass Isoindoles
Intermediate Tree Nodes Not available
Direct Parent Isoindoles
Alternative Parents N-substituted imidazoles  Benzenoids  Heteroaromatic compounds  Secondary alcohols  Azacyclic compounds  Organonitrogen compounds  Hydrocarbon derivatives  
Molecular Framework Aromatic heteropolycyclic compounds
Substituents Isoindole - Benzenoid - N-substituted imidazole - Heteroaromatic compound - Imidazole - Azole - Secondary alcohol - Azacycle - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Alcohol - Aromatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as isoindoles. These are heteropolycyclic compounds with a structure containing isoindole, a benzo-fused pyrrole.
External Descriptors Not available

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
TDO2 Tchem Tryptophan 2,3-dioxygenase (2 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (18 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2B6 Tchem Cytochrome P450 2B6 (1338 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
IDO1 Tchem Indoleamine 2,3-dioxygenase (6650 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Tdo2 Tryptophan 2,3-dioxygenase (8 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mus musculus (284745 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
LLTC cell line (101 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Ido1 Indoleamine 2,3-dioxygenase 1 (313 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 488202057
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202057
IUPAC Name 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
INCHI InChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5,8-9,11-13,16,18,21H,1-3,6-7,10H2
InChIKey YTRRAUACYORZLX-UHFFFAOYSA-N
Smiles C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
Isomeric SMILES C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O
Molecular Weight 282.38
Reaxy-Rn 22999288
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22999288&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

20 results found

Lot Number Certificate Type Date Item
H2307274 Certificate of Analysis May 12, 2025 N129887
H2307075 Certificate of Analysis May 12, 2025 N129887
D2328098 Certificate of Analysis Feb 07, 2025 N129887
D2328109 Certificate of Analysis Feb 07, 2025 N129887
E2304206 Certificate of Analysis Feb 07, 2025 N129887
D2328119 Certificate of Analysis Feb 07, 2025 N129887
L2215721 Certificate of Analysis Sep 18, 2024 N129887
L2215719 Certificate of Analysis Sep 18, 2024 N129887
G2226410 Certificate of Analysis May 20, 2024 N129887
B2217040 Certificate of Analysis Dec 19, 2023 N129887
J2326643 Certificate of Analysis Oct 11, 2023 N129887
J2326624 Certificate of Analysis Oct 11, 2023 N129887
H2307063 Certificate of Analysis Jul 21, 2023 N129887
D2304206 Certificate of Analysis Apr 08, 2023 N129887
D2328120 Certificate of Analysis Apr 08, 2023 N129887
L2215720 Certificate of Analysis Aug 29, 2022 N129887
G2226428 Certificate of Analysis Jun 14, 2022 N129887
G2226411 Certificate of Analysis Jun 14, 2022 N129887
H1616020 Certificate of Analysis Apr 25, 2022 N129887
B2217041 Certificate of Analysis Jan 10, 2022 N129887

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Chemical and Physical Properties

Solubility DMSO 56 mg/mL Water <1 mg/mL Ethanol 56 mg/mL
Molecular Weight 282.400 g/mol
XLogP3 3.500
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count 3
Exact Mass 282.173 Da
Monoisotopic Mass 282.173 Da
Topological Polar Surface Area 38.100 Ų
Heavy Atom Count 21
Formal Charge 0
Complexity 355.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 2
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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