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NFAT Transcription Factor Regulator-1 - 10mM in DMSO, high purity , CAS No.245747-71-1(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 245747-71-1(DMSO)
Molecular Weight: 416.28

In stock

Item Number

N655743

Grouped product items
SKU	Size	Availability	Price	Qty
N655743-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$192.90

View related series

Compound libraries (12325) Immunology/Inflammation (1929) Interleukin Related (129)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	NFAT Transcription Factor Regulator-1 is an IL-2 synthesis inhibitor with an IC 50 of 182 nM.
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	NFAT Transcription Factor Regulator-1 is an IL-2 synthesis inhibitor with an IC 50 of 182 nM. In Vitro NFAT Transcription Factor Regulator-1 (compound example 19) inhibits IL-2 synthesis with an IC 50 of 182 nM. NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC 50 s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo NFAT Transcription Factor Regulator-1 is found to have an inhibitory potency approximately 10-fold better than that of cyclosporine. Comparable inhibitory effects on T-cell IL-2 production are obtained with NFAT Transcription Factor Regulator-1 and cyclosporine at doses of 3.0 and 30 mg/kg, po, respectively. The efficacies achieved in monkeys in vivo for blocking T-cell cytokine production suggest that NFAT Transcription Factor Regulator-1 has potential similar to that of cyclosporine for use in transplantation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IL-2 182 nM (IC 50 )

Names and Identifiers

Smiles	C1=CC(=CC=C1NC(=O)C2=C(C=NC=C2)F)N3C(=CC(=N3)C(F)(F)F)OC(F)F
Molecular Weight	416.28

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