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NF-κΒ activator 2 - 98%, high purity , CAS No.2375281-44-8

COA

Grade & Purity:

≥98%

Cas Number: 2375281-44-8
Molecular Weight: 298.27
PubChem CID: 139434520

In stock

Item Number

N646479

Grouped product items
SKU	Size	Availability	Price
N646479-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
N646479-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$800.90
N646479-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,650.90
N646479-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,550.90

View related series

NF-κB (747)

Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	NF-κΒ activator 2 is a potent and orally active NF-ҡB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD 2 through increasing NF-ҡB expression and activation. NF-κΒ activator 2 can be used for the research of amyotrophic lateral sclerosis (ALS) In Vitro NF-κΒ activator 2 (compound 61) (1 μM, 6 h) induces SOD 2 mRNA expression in SH-SY5Y neuroblastoma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo NF-κΒ activator 2 (1 mg/kg; i.v.) displays a suitable half-life (0.96 h) in mice . NF-κΒ activator 2 (5 mg/kg; p.o.) displays a comparable half-life (2.86 h), oral bioavailability (15.6%), and C max (92 ng/mL) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:NF-κB 1.58 μM (EC 50 )

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-[2-(2-fluoroanilino)-1,3-oxazol-5-yl]benzoic acid
INCHI	InChI=1S/C16H11FN2O3/c17-12-6-1-2-7-13(12)19-16-18-9-14(22-16)10-4-3-5-11(8-10)15(20)21/h1-9H,(H,18,19)(H,20,21)
InChIKey	VGJMPWREFUKMAD-UHFFFAOYSA-N
Smiles	C1=CC=C(C(=C1)NC2=NC=C(O2)C3=CC(=CC=C3)C(=O)O)F
Isomeric SMILES	C1=CC=C(C(=C1)NC2=NC=C(O2)C3=CC(=CC=C3)C(=O)O)F
PubChem CID	139434520
Molecular Weight	298.27

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 250 mg/mL (838.17 mM; Need ultrasonic)
Molecular Weight	298.270 g/mol
XLogP3	3.500
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	298.075 Da
Monoisotopic Mass	298.075 Da
Topological Polar Surface Area	75.400 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	396.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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