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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab170532-100μg
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100μg |
10
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$39.90
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Ab170532-1mg
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1mg |
4
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$177.90
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Ab170532-5mg
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5mg |
1
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$447.90
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Ab170532-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$747.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Nemolizumab (anti-IL-31Ra) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL31RA, >95%, high purity, Human IgG2, Antibody of Interleukin-31 receptor; α subunit |
|---|---|
| Synonyms | Cytokine receptor-like 3 | GLM-R | Gp130-like monocyte receptor | Gp130-like receptor | hGLM-R | IL-31 receptor subunit alpha | IL-31R subunit alpha | IL-31RA | IL-31R-alpha | ZcytoR17 |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | IL31RA |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of Interleukin-31 receptor; α subunit |
| Product Description |
Nemolizumab (anti-IL-31Ra) is a humanized antihuman interleukin-31 receptor A monoclonal antibody that inhibits the binding of interleukin-31 (IL-31) to its receptor and subsequent signal transduction. Nemolizumab can used be in research of atopic dermatitis (AD). |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG2 |
| Light Chain Type | kappa |
| SDS-PAGE | 26.5 kDa (Light Chain) & 54.0 kDa (Heavy Chain), under reducing conditions; 175.4 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 1476039-58-3 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Nemolizumab (anti-IL-31Ra) (Ab170532) - SEC
The purity of Nemolizumab (anti-IL-31Ra) (Ab170532) is more than 95% verified by HPLC.
Nemolizumab (anti-IL-31Ra) (Ab170532) - ELISA
Immobilized Human IL-31RA - Fc tag at 2 μg/mL can bind Nemolizumab (anti-IL-31Ra) (Ab170532) with the EC₅₀ of 20.79 ng/mL.
| Application | Dilution info |
|---|---|
| IF/ICC |
1/50-1/200
|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Mar 25, 2024 | Ab170532 | |
| Certificate of Analysis | Mar 25, 2024 | Ab170532 | |
| Certificate of Analysis | Mar 25, 2024 | Ab170532 |