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Nemolizumab (anti-IL-31Ra) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL31RA, >95%, high purity, Human IgG2, Antibody of Interleukin-31 receptor; α subunit, Antibody of Interleukin-31 receptor; α subunit

    Application:
  • IF/ICC
  • Host species: Human
  • Reactive species: Cynomolgus monkey,Human
  • Isotype: Human IgG2
  • Conjugation: Unconjugated
In stock
Item Number
Ab170532
Grouped product items
SKU Size
Availability
Price Qty
Ab170532-100μg
100μg
10
$39.90
Ab170532-1mg
1mg
4
$177.90
Ab170532-5mg
5mg
1
$447.90
Ab170532-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$747.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG2; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product Name Nemolizumab (anti-IL-31Ra) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL31RA, >95%, high purity, Human IgG2, Antibody of Interleukin-31 receptor; α subunit
Synonyms Cytokine receptor-like 3 | GLM-R | Gp130-like monocyte receptor | Gp130-like receptor | hGLM-R | IL-31 receptor subunit alpha | IL-31R subunit alpha | IL-31RA | IL-31R-alpha | ZcytoR17
Specifications & Purity Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host species Human
Specificity IL31RA
Application ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
Conjugation Unconjugated
Grade Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type INHIBITOR
Mechanism of action Antibody of Interleukin-31 receptor; α subunit
Product Description

Nemolizumab (anti-IL-31Ra) is a humanized antihuman interleukin-31 receptor A monoclonal antibody that inhibits the binding of interleukin-31 (IL-31) to its receptor and subsequent signal transduction. Nemolizumab can used be in research of atopic dermatitis (AD).
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg

Product Properties

Antibody Type Primary antibody
Clonality Recombinant
Isotype Human IgG2
Light Chain Type kappa
SDS-PAGE 26.5 kDa (Light Chain) & 54.0 kDa (Heavy Chain), under reducing conditions; 175.4 kDa, under non-reducing conditions.
Purification Method Protein A purified
Purity >95%
Source CHO supernatant
Shape Liquid
Concentration See COA
Storage Temp Store at -80°C,Avoid repeated freezing and thawing
Shipped In Ice chest + Ice pads
Stability And Storage Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.
CAS 1476039-58-3

Associated Targets(Human)

IL31RA Tbio Interleukin-31 receptor subunit alpha (0 Activities)
Activity Type Activity Value -log(M) Mechanism of Action Activity Reference Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Images

Nemolizumab (anti-IL-31Ra) (Ab170532) - SEC
The purity of Nemolizumab (anti-IL-31Ra) (Ab170532) is more than 95% verified by HPLC.

Nemolizumab (anti-IL-31Ra) (Ab170532) - ELISA
Immobilized Human IL-31RA - Fc tag at 2 μg/mL can bind Nemolizumab (anti-IL-31Ra) (Ab170532) with the EC₅₀ of 20.79 ng/mL.

Application

Application Dilution info
IF/ICC

1/50-1/200

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
ZJ24F0303672 Certificate of Analysis Mar 25, 2024 Ab170532
ZJ24F0303671 Certificate of Analysis Mar 25, 2024 Ab170532
ZJ24F0303670 Certificate of Analysis Mar 25, 2024 Ab170532

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