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Navoximod - 98%, high purity , CAS No.1402837-78-8

COA

Grade & Purity:

≥98%

Cas Number: 1402837-78-8
Molecular Weight: 316.37
PubChem CID: 70914230
PubChem SID: 504771996

In stock

Item Number

N414294

Grouped product items
SKU	Size	Availability	Price
N414294-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$118.90
N414294-5mg	5mg	3	$414.90
N414294-10mg	10mg	3	$622.90
N414294-25mg	25mg	2	$806.90
N414294-50mg	50mg	2	$989.90

IDO/TDO Inhibitors

View related series

Amino Acid/Protein Metabolism (1836) Indoleamine 2,3-Dioxygenase (IDO) (59) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms	NLG-919 \| NLG-919 Navoximod \| US10233190, Example 1484 \| F85292 \| (1R,4r)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol \| Navoximod \| Navoximod;GDC-0919;IDO-IN-7;NLG-1488 \| NAVOXIMOD [INN] \| NLG-?919 \| UNII-926SHL95NC
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM.
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Information Navoximod Navoximod (GDC-0919, NLG-919) is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) pathway with Ki of 7 nM and EC50 of 75 nM. Targets IDO (Cell-free assay); IDO (Cell-free assay) 7 nM(Ki); 75 nM(EC50) In vitro NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) with ED50 of 120 nM.\xa0NLG919 increases the cytotoxic activity of paclitaxel toward B16-F10 cells in the presence of pretreatment with interferon (IFN)-γ in vitro. In vivo In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA.Immune competent mice are injected orthotopically with genetically engineered murine glioma cells and treated with GDC-0919 alone or combined with RT. GDC-0919 demonstrates potent inhibition of this node and effectively crosses the blood brain barrier. Although GDC-0919 as a single agent does not demonstrate anti-tumor activity, it has a strong potential for enhancing RT response in glioblastoma, which is further augmented with a hypofractionated regimen. Cell Research(from reference) Cell lines：the murine melanoma cell line B16-F10 Concentrations：100\u2009nM Incubation Time：12\u2009h, 24\u2009h, 48\u2009h, 72\u2009h

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Isoindoles and derivatives
    - Subclass Isoindoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Isoindoles and derivatives
Subclass	Isoindoles
Intermediate Tree Nodes	Not available
Direct Parent	Isoindoles
Alternative Parents	Cyclohexanols N-substituted imidazoles Benzenoids Aryl fluorides Heteroaromatic compounds Cyclic alcohols and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Isoindole - Cyclohexanol - Benzenoid - N-substituted imidazole - Aryl halide - Aryl fluoride - Heteroaromatic compound - Imidazole - Cyclic alcohol - Azole - Secondary alcohol - Azacycle - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alcohol - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as isoindoles. These are heteropolycyclic compounds with a structure containing isoindole, a benzo-fused pyrrole.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	2.224
hba_count	1
HBD Count	2
Rotatable Bond	3

Names and Identifiers

Pubchem Sid	504771996
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771996
IUPAC Name	4-[(1R)-2-[(5S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl]-1-hydroxyethyl]cyclohexan-1-ol
INCHI	InChI=1S/C18H21FN2O2/c19-14-3-1-2-13-16-9-20-10-21(16)15(18(13)14)8-17(23)11-4-6-12(22)7-5-11/h1-3,9-12,15,17,22-23H,4-8H2/t11?,12?,15-,17+/m0/s1
InChIKey	YGACXVRLDHEXKY-LHPNLFKDSA-N
Smiles	C1CC(CCC1C(CC2C3=C(C=CC=C3F)C4=CN=CN24)O)O
Isomeric SMILES	C1CC(CCC1[C@@H](C[C@H]2C3=C(C=CC=C3F)C4=CN=CN24)O)O
Molecular Weight	316.37
Reaxy-Rn	30199924
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30199924&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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5 results found

Lot Number	Certificate Type	Date	Item
I2205237	Certificate of Analysis	Jun 09, 2025	N414294
I2205311	Certificate of Analysis	Jun 09, 2025	N414294
I2205312	Certificate of Analysis	Jun 09, 2025	N414294
I2205310	Certificate of Analysis	Jun 09, 2025	N414294
L2420228	Certificate of Analysis	Jun 15, 2022	N414294

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 63 mg/mL (199.13 mM); Ethanol: 63 mg/mL (199.13 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	63
DMSO(mM) Max Solubility	199.133925467016
Water(mg / mL) Max Solubility	＜1
Molecular Weight	316.400 g/mol
XLogP3	2.100
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	316.159 Da
Monoisotopic Mass	316.159 Da
Topological Polar Surface Area	58.300 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	416.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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