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Nampt-IN-5 - 10mM in DMSO, high purity , CAS No.2380013-17-0(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 2380013-17-0(DMSO)
Molecular Weight: 427.50

In stock

Item Number

N656732

Grouped product items
SKU	Size	Availability	Price	Qty
N656732-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$440.90

View related series

Compound libraries (12325) Cytochrome P450 (241) Metabolic Enzyme/Protease (4860) NAMPT (29)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively.
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively In Vitro Nampt-IN-5 (compound 27) (0-10 nM; 3 days) has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min•mg), CYP3A4 inhibition value (0.75 μM), Sol 6.8 : 0.056 mM; MDCK P app AB: 18.6. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Nampt-IN-5 (5-30 mg/kg; p.o. twice daily for 4 days) causes a significant amount of body weight loss in nude mice relative to vehicle . Nampt-IN-5 (10 mg/kg; p.o.) exhibits T 1/2 (2.1 h), C max (29112 nM), and AUC (61984 nM•h) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:NAMPT, CYP3A4

Names and Identifiers

Smiles	CCOC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)NC(=O)N4CC(C4)C5=CN=CC=C5
Molecular Weight	427.50

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