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MPP+ iodide - ≥98%, high purity , CAS No.36913-39-0

6 Citations

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 36913-39-0
Molecular Weight: 297.13
MDL number: MFCD00055096
PubChem CID: 10924457
PubChem SID: 504765742

In stock

Item Number

N137206

Grouped product items
SKU	Size	Availability	Price
N137206-25mg	25mg	3	$59.90
N137206-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$197.90
N137206-500mg	500mg	5	$891.90
N137206-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,603.90

Dopaminergic selective neurotoxin

View related series

Glucose Metabolism (1943) Metabolic Enzyme/Protease (4860) Mitochondrial Metabolism (118)

Basic Description

Synonyms	HY-W008719 \| MPP+ iodide \| FT-0672164 \| Q27284640 \| SCHEMBL2203363 \| MPP iodide \| CS-W009435 \| UNII-N708D004VE \| N-Methyl-4-phenylpyridiniumIodide \| D95477 \| MPP+ (iodide) \| Cyperquat iodide \| N-Methyl-4-phenylpyridinium iodide \| Pyridinium, 1-methyl-4-ph
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.Dopaminergic selective neurotoxin. Active MPTP metabolite. Interferes with oxidative phosphorylation and induces mitochondrial dysfunction. Deplete cellular ATP. Shows Parkinson effects i
Shipped In	Normal
Grade	Moligand™
Note	Unstable; make up solutions fresh and use immediately. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Product Describtion: 1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide. Product Application： MPP+ iodide has been used: to induce oxidative stress in zebrafish embryos for the inhibition of glutamate uptake in mitochondria of astrocytes in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Phenylpyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Phenylpyridines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyridines
Alternative Parents	N-methylpyridinium compounds Pyridinium derivatives Benzene and substituted derivatives Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Organic iodide salts Hydrocarbon derivatives Organic cations
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	4-phenylpyridine - N-methylpyridinium - Benzenoid - Pyridinium - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic iodide salt - Organic salt - Organonitrogen compound - Organic cation - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLC18A2 Tclin Synaptic vesicular amine transporter (118 Activities)

Discover Target: SLC18A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SH-SY5Y (11521 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504765742
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504765742
IUPAC Name	1-methyl-4-phenylpyridin-1-ium;iodide
INCHI	InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
InChIKey	RFDFRDXIIKROAI-UHFFFAOYSA-M
Smiles	C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]
Isomeric SMILES	C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-]
WGK Germany	3
RTECS	UU6580000
PubChem CID	10924457
UN Number	2811
Packing Group	II
Molecular Weight	297.13

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number	Certificate Type	Date	Item
F2525009	Certificate of Analysis	Jul 02, 2025	N137206
L2205275	Certificate of Analysis	Sep 18, 2024	N137206
L2205276	Certificate of Analysis	Sep 18, 2024	N137206
L2205271	Certificate of Analysis	Sep 18, 2024	N137206
B2512022	Certificate of Analysis	Sep 18, 2024	N137206
A2506250	Certificate of Analysis	Sep 18, 2024	N137206
C2219011	Certificate of Analysis	Jan 04, 2024	N137206
C2219016	Certificate of Analysis	Jan 04, 2024	N137206
E2431057	Certificate of Analysis	Sep 29, 2022	N137206
L2205274	Certificate of Analysis	Sep 29, 2022	N137206
F2307383	Certificate of Analysis	Sep 29, 2022	N137206
E2429059	Certificate of Analysis	Sep 29, 2022	N137206
I2405050	Certificate of Analysis	Sep 29, 2022	N137206
C2219010	Certificate of Analysis	Jan 05, 2022	N137206
C2219005	Certificate of Analysis	Jan 05, 2022	N137206

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Chemical and Physical Properties

Solubility	H2O: >10 mg/mL, soluble
Sensitivity	light ＆ Moisture sensitive
Molecular Weight	297.130 g/mol
XLogP3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	297.001 Da
Monoisotopic Mass	297.001 Da
Topological Polar Surface Area	3.900 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	141.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Documents & Articles

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