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ML148 - 10mM in DMSO, high purity , CAS No.451496-96-1(DMSO)

COA

Grade & Purity:

10mM in DMSO

Cas Number: 451496-96-1(DMSO)
Molecular Weight: 319.4

In stock

Item Number

M654864

Grouped product items
SKU	Size	Availability	Price	Qty
M654864-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$253.90

View related series

15-PGDH (5) Compound libraries (12325) Metabolic Enzyme/Protease (4860)

Basic Description

Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	ML148 is a potent and selective 15-PGDH inhibitor with an IC 50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways.
Storage Temp	Store at -80°C
Shipped In	Dry ice packs + Cold packs This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	ML148 is a potent and selective 15-PGDH inhibitor with an IC 50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways In Vitro ML148 (compound 13) shows selectivity with IC 50 s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively. ML148 (10, 20 nM) decrease V max by 25% and reduces the apparent K m by half at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC 50 : 56 nM (15-PGDH)

Associated Targets(Human)

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (1 Activities)

Discover Target: HPGD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Smiles	CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4
Molecular Weight	319.4

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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