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MK 386 - ≥98%(HPLC), high purity , CAS No.158493-17-5

COA

Grade & Purity:

≥98%(HPLC)

Cas Number: 158493-17-5
Molecular Weight: 415.69
PubChem CID: 9888107

In stock

Item Number

M286985

Grouped product items
SKU	Size	Availability	Price	Qty
M286985-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,169.90

Potent, selective human type 1 5α-reductase inhibitor

View related series

Lipid metabolism (1912)

Basic Description

Synonyms	2H-Indeno(5,4-f)quinolin-2-one, 7-((1R)-1,5-dimethylhexyl)hexadecahydro-1,4a,6a,10-tetramethyl-, (4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)- \| 2H-INDENO(5,4-F)QUINOLIN-2-ONE, 7-(1,5-DIMETHYLHEXYL)HEXADECAHYDRO-1,4A,6A,10-TETRAMETHYL-, (4AR-(4A.ALPHA.,4B.BETA.,6A.A
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50= 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50= 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting s
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Steroids and steroid derivatives
    - Subclass Androstane steroids

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Steroids and steroid derivatives
Subclass	Androstane steroids
Intermediate Tree Nodes	Not available
Direct Parent	Androgens and derivatives
Alternative Parents	3-oxo-5-alpha-steroids 3-oxo-4-azasteroids 4-azasteroids and derivatives Quinolidines Piperidinones Delta lactams Tertiary carboxylic acid amides Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Androgen-skeleton - 3-oxosteroid - Oxosteroid - 3-oxo-5-alpha-steroid - 3-oxo-4-azasteroid - 4-azasteroid - Azasteroid - Quinolidine - Piperidinone - Delta-lactam - Piperidine - Tertiary carboxylic acid amide - Carboxamide group - Lactam - Organoheterocyclic compound - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Aliphatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(1R,3aS,3bS,4S,5aR,9aR,9bS,11aR)-4,6,9a,11a-tetramethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1H-indeno[5,4-f]quinolin-7-one
INCHI	InChI=1S/C28H49NO/c1-18(2)9-8-10-19(3)21-11-12-22-26-20(4)17-24-28(6,16-14-25(30)29(24)7)23(26)13-15-27(21,22)5/h18-24,26H,8-17H2,1-7H3/t19-,20+,21-,22+,23+,24-,26+,27-,28-/m1/s1
InChIKey	XUTZDXHKQDPUMA-MVJJLJOTSA-N
Smiles	CC1CC2C(CCC(=O)N2C)(C3C1C4CCC(C4(CC3)C)C(C)CCCC(C)C)C
Isomeric SMILES	C[C@H]1C[C@@H]2[C@](CCC(=O)N2C)([C@@H]3[C@@H]1[C@@H]4CC[C@@H]([C@]4(CC3)C)[C@H](C)CCCC(C)C)C
Molecular Weight	415.69
Reaxy-Rn	24888213
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24888213&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 41.57, Max Conc. mM: 100
Molecular Weight	415.700 g/mol
XLogP3	8.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	5
Exact Mass	415.381 Da
Monoisotopic Mass	415.381 Da
Topological Polar Surface Area	20.300 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	643.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	9
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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