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Minocycline hydrochloride - 2mM in Water, high purity , CAS No.13614-98-7

14 Citations

COA

Grade & Purity:

2mM in Water

Cas Number: 13614-98-7
Molecular Weight: 493.94
EC Number: 237-099-7
PubChem CID: 54685925

In stock

Item Number

M421372

Grouped product items
SKU	Size	Availability	Price	Qty
M421372-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69.90

Antibiotic. Demonstrates multiple effects.

View related series

Antibiotic (1629) Apoptosis (4276) Bacterial (3013) Compound libraries (12325) Glucose Metabolism (1943) Intrinsic Pathway (690) Ion channel (2197)

Basic Description

Synonyms	MINOCYCLINE HYDROCHLORIDE \| 13614-98-7 \| Minocycline HCl \| Arestin \| Solodyn \| Minomycin \| Minocin \| Dynacin \| Periocline \| Ximino \| Minocycline (hydrochloride) \| Vectrin \| Minomax \| (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-
Specifications & Purity	2mM in Water
Biochemical and Physiological Mechanisms	Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Minocycline acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. M
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	Minocycline hydrochloride has been used: · to prepare nanoliposomes to check its effect on macrophages · for the inhibition of neuroinflammation and neuropathic pain · to treat glioma in murine GL261 glioma cells

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Tetracyclines

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Tetracyclines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Tetracyclines
Alternative Parents	Naphthols and derivatives Dialkylarylamines 1-hydroxy-2-unsubstituted benzenoids Aralkylamines Cyclohexenones Vinylogous acids Tertiary alcohols Trialkylamines Cyclic alcohols and derivatives Polyols Carboximidic acids Enols Organic oxides Hydrochlorides Hydrocarbon derivatives Organopnictogen compounds
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Tetracycline - 1-naphthol - Naphthalene - Tertiary aliphatic/aromatic amine - Dialkylarylamine - 1-hydroxy-2-unsubstituted benzenoid - Cyclohexenone - Aralkylamine - Benzenoid - Cyclic alcohol - Tertiary alcohol - Vinylogous acid - Ketone - Tertiary amine - Tertiary aliphatic amine - Cyclic ketone - Polyol - Enol - Carboximidic acid derivative - Carboximidic acid - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Alcohol - Organic nitrogen compound - Amine - Hydrochloride - Carbonyl group - Aromatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as tetracyclines. These are polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Names and Identifiers

IUPAC Name	(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
INCHI	InChI=1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChIKey	WTJXVDPDEQKTCV-VQAITOIOSA-N
Smiles	CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
Isomeric SMILES	CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
WGK Germany	3
RTECS	QI7630500
PubChem CID	54685925
Molecular Weight	493.94
Reaxy-Rn	4836328

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Sensitivity	Heat sensitive
Specific Rotation[α]	-170 to -180 deg(C=0.5、0.1mol/L HCl)
Flash Point(°F)	230°F
Flash Point(°C)	>110℃
Boil Point(°C)	813℃
Melt Point(°C)	205-210℃
Molecular Weight	493.900 g/mol
XLogP3
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	493.162 Da
Monoisotopic Mass	493.162 Da
Topological Polar Surface Area	165.000 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	971.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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