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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
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Ab175598-100μg
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100μg |
10
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$69.90
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Ab175598-1mg
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1mg |
4
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$339.90
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Ab175598-5mg
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5mg |
1
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$869.90
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Ab175598-10mg
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10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
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$1,379.90
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Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Milatuzumab (anti-CD74) - Primary antibody, specific to CD74, >95%, high purity, Human IgG1, Antibody of CD74 |
|---|---|
| Synonyms | CD 74 antibody | CD74 antibody | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody | CD74 antigen antibody | CD74 molecule antibody | CD74 molecule, major histocompatibility complex, class II in |
| Specifications & Purity | Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Host species | Human |
| Specificity | CD74 |
| Conjugation | Unconjugated |
| Grade | Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | ANTAGONIST |
| Mechanism of action | Antibody of CD74 |
| Product Description |
Milatuzumab (anti-CD74) is a humanized anti-CD74 monoclonal antibody. CD74, a integral membrane protein, is associated with the promotion of B-cell growth and survival. Milatuzumab (anti-CD74) causes free radical oxygen generation, and loss of mitochondrial membrane potential. Milatuzumab (anti-CD74) also decreases CD20/CD74 aggregates and cell adhesion, to lead to cell death. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.7 kDa (Light Chain) & 50.7 kDa (Heavy Chain), under reducing conditions; 199.9 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Purity | >95% |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. |
| CAS | 899796-83-9 |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Milatuzumab (anti-CD74) (Ab175598) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling CD74 (red) with Milatuzumab (anti-CD74) (Ab175598). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Milatuzumab (anti-CD74) (Ab175598) - SEC
The purity of Milatuzumab (anti-CD74) (Ab175598) is more than 95% verified by HPLC.
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Apr 01, 2024 | Ab175598 | |
| Certificate of Analysis | Apr 01, 2024 | Ab175598 | |
| Certificate of Analysis | Apr 01, 2024 | Ab175598 |
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