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Small Molecules & Compound Libraries
Signaling Pathways
Neuronal Signaling
Glucosylceramide Synthase (GCS)
Miglustat hydrochloride - ≥98％, high purity , CAS No.210110-90-0

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Miglustat hydrochloride - ≥98％, high purity , CAS No.210110-90-0

COA

Grade & Purity:

≥98%

Cas Number: 210110-90-0
Molecular Weight: 255.74
PubChem CID: 6603107

In stock

Item Number

M288367

Grouped product items
SKU	Size	Availability	Price
M288367-5mg	5mg	3	$77.90
M288367-10mg	10mg	2	$137.90
M288367-25mg	25mg	2	$272.90
M288367-50mg	50mg	1	$472.90
M288367-100mg	100mg	1	$829.90

α-glucosidase I and II inhibitor; also inhibits ceramide-specific glycosyltransferases and exhibits broad spectrum antiviral activity

View related series

Glucosylceramide Synthase (GCS) (14) Neuronal Signaling (3320)

Basic Description

Synonyms	SMR000058560 \| Miglustat HCl \| Miglustat hydrochloride \| (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride \| AKOS024457437 \| (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-,3,4,5-Piperidinetriol Hydrochloride \| AKOS000269030 \| E73460 \|
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Orally activeα-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ERα-glucosidases I and II. Also has broad spectrum antiviral activity.De
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Piperidines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Piperidines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Piperidines
Alternative Parents	Trialkylamines Secondary alcohols 1,2-aminoalcohols Polyols Azacyclic compounds Primary alcohols Organopnictogen compounds Organic zwitterions Organic chloride salts Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	Piperidine - 1,2-aminoalcohol - Secondary alcohol - Tertiary amine - Tertiary aliphatic amine - Polyol - Azacycle - Organic nitrogen compound - Organic salt - Organic zwitterion - Hydrochloride - Organic chloride salt - Hydrocarbon derivative - Primary alcohol - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Amine - Alcohol - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as piperidines. These are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)

Discover Target: GAA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol;hydrochloride
INCHI	InChI=1S/C10H21NO4.ClH/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12;/h7-10,12-15H,2-6H2,1H3;1H/t7-,8+,9-,10-;/m1./s1
InChIKey	QPAFAUYWVZMWPR-ZSOUGHPYSA-N
Smiles	CCCCN1CC(C(C(C1CO)O)O)O.Cl
Isomeric SMILES	CCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O.Cl
Molecular Weight	255.74
Reaxy-Rn	59683538
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=59683538&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
A2408522	Certificate of Analysis	Dec 08, 2023	M288367
A2408531	Certificate of Analysis	Dec 08, 2023	M288367
A2408533	Certificate of Analysis	Dec 08, 2023	M288367
A2408534	Certificate of Analysis	Dec 08, 2023	M288367
A2408656	Certificate of Analysis	Dec 08, 2023	M288367
A2408657	Certificate of Analysis	Dec 08, 2023	M288367
A2408658	Certificate of Analysis	Dec 08, 2023	M288367
A2408659	Certificate of Analysis	Dec 08, 2023	M288367
A2408660	Certificate of Analysis	Dec 08, 2023	M288367
A2408661	Certificate of Analysis	Dec 08, 2023	M288367

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 19.18, Max Conc. mM: 75; Solvent:DMSO, Max Conc. mg/mL: 19.18, Max Conc. mM: 75
Molecular Weight	255.740 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	255.124 Da
Monoisotopic Mass	255.124 Da
Topological Polar Surface Area	84.200 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	190.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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