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Meropenem trihydrate - 98%, high purity , CAS No.119478-56-7

1 Citations COA COA
    Grade & Purity:
  • ≥98%
In stock
Item Number
M166349
Grouped product items
SKU Size
Availability
 Price Qty
M166349-250mg
250mg
3
$48.90
M166349-1g
1g
3
$150.90
M166349-5g
5g
3
$521.90
M166349-25g
25g
2
$2,346.90
Wish List
Bulk Order  SDS  DATASHEET  Specification Sheet

Broad-spectum β-lactam antibiotic

View related series
Anti-infection (2803) Antibiotic (1629) Bacterial (3013) Carbapenem antibiotics (2)

Basic Description

Synonyms s4846 | (4R,5S,6S)-3-(((3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate | Meropenem trihydrate, European Pharmacopoeia (EP) Reference Standard | 1-Azabicycl
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.Broad-spectrum β-lactam antibiotic. Blood-brain barrier permeable.
Storage Temp Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic active against both Gram-positive and Gram-negative bacteria. Meropenem trihydrate (MRP) belongs to the carbapenem group of compounds. It is susceptible to degradation at high temperature and humidity. It is soluble in methanol-water or acetone-water combinations. It is used as an antibacterial agent for treating meningitis and pneumonia.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Organoheterocyclic compounds
Class Lactams
Subclass Beta lactams
Intermediate Tree Nodes Carbapenems
Direct Parent Thienamycins
Alternative Parents Proline and derivatives  Alpha amino acid amides  Pyrroline carboxylic acids  Pyrrolidinecarboxamides  Azepines  Vinylogous thioesters  Tertiary carboxylic acid amides  Thioenol ethers  Secondary alcohols  Amino acids  Azetidines  Sulfenyl compounds  Monocarboxylic acids and derivatives  Azacyclic compounds  Dialkylamines  Carboxylic acids  Carbonyl compounds  Hydrocarbon derivatives  Organic oxides  Organopnictogen compounds  
Molecular Framework Aliphatic heteropolycyclic compounds
Substituents Thienamycin - Proline or derivatives - Alpha-amino acid amide - Alpha-amino acid or derivatives - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Pyrroline carboxylic acid - Pyrroline carboxylic acid or derivatives - Azepine - Vinylogous thioester - Pyrrolidine - Pyrroline - Tertiary carboxylic acid amide - Amino acid or derivatives - Azetidine - Carboxamide group - Amino acid - Thioenolether - Secondary alcohol - Secondary amine - Sulfenyl compound - Azacycle - Carboxylic acid derivative - Carboxylic acid - Secondary aliphatic amine - Monocarboxylic acid or derivatives - Amine - Alcohol - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Organic oxide - Organic oxygen compound - Aliphatic heteropolycyclic compound
Description This compound belongs to the class of organic compounds known as thienamycins. These are beta-lactam antibiotics that differ from penicillins in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain.
External Descriptors hydrate

Product Properties

ALogP -2.4

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Proteus vulgaris (5823 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Aspergillus niger (16508 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mycolicibacterium smegmatis (8003 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Acholeplasma laidlawii (17 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Candida albicans (78123 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Xanthomonas campestris (200 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Bacillus spizizenii (1898 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mucor racemosus (46 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504758746
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504758746
IUPAC Name (4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;trihydrate
INCHI InChI=1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1
InChIKey CTUAQTBUVLKNDJ-OBZXMJSBSA-N
Smiles CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O.O.O.O
Isomeric SMILES C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)N(C)C)C(=O)O)[C@@H](C)O.O.O.O
WGK Germany 3
Alternate CAS 96036-03-2
PubChem CID 441129
Molecular Weight 437.51

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number Certificate Type Date Item
I2122182 Certificate of Analysis Jul 11, 2024 M166349
I2122184 Certificate of Analysis Jul 11, 2024 M166349
I2122185 Certificate of Analysis Jul 11, 2024 M166349
K2322445 Certificate of Analysis Jan 09, 2023 M166349
K2322446 Certificate of Analysis Jan 09, 2023 M166349
K2212287 Certificate of Analysis Aug 29, 2022 M166349
K2212288 Certificate of Analysis Aug 29, 2022 M166349
K2212293 Certificate of Analysis Aug 29, 2022 M166349
K2212289 Certificate of Analysis Aug 29, 2022 M166349
A2506255 Certificate of Analysis Aug 29, 2022 M166349

Chemical and Physical Properties

Solubility Soluble in aqueous solution at approximately 5mg/ml
Sensitivity heat sensitive
Specific Rotation[α] -18° (C=0.44,H2O)
Molecular Weight 437.500 g/mol
XLogP3
Hydrogen Bond Donor Count 6
Hydrogen Bond Acceptor Count 10
Rotatable Bond Count 5
Exact Mass 437.183 Da
Monoisotopic Mass 437.183 Da
Topological Polar Surface Area 138.000 Ų
Heavy Atom Count 29
Formal Charge 0
Complexity 679.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 6
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 4

Alternative Products

  1. Meropenem trihydrate
    Meropenem trihydrate
    • 10mM in DMSO

    Starting at $69.90

Solution Calculators

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