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MEDICA 16 - 98%, high purity , CAS No.87272-20-6, Agonist of FFA1 receptor

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 87272-20-6
Molecular Weight: 342.51
PubChem CID: 121871

In stock

Item Number

M288258

Grouped product items
SKU	Size	Availability	Price
M288258-5mg	5mg	2	$89.90
M288258-10mg	10mg	2	$139.90
M288258-25mg	25mg	1	$309.90
M288258-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$509.90
M288258-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$819.90

FFA1 (GPR40) agonist; also inhibits ATP citrate lyase

View related series

ATP Citrate Lyase (14) Class A GPCR (4138) FFA1 receptor Agonist (17) Fluorine PEG (2) Free Fatty Acid Receptor (52) GPCR/G Protein (3172) Lipid metabolism (1912) Metabolic Enzyme/Protease (4860) PROTAC linker (720)

Basic Description

Synonyms	3,3,14,14-Tetramethyl-hexadecane-1,16-dioic acid \| SR-01000946665 \| di-tert-butyl[2',4',6'-tris(propan-2-yl)-[1,1'-biphenyl]-2-yl]phosphane \| TC257FLPCK \| Q27132978 \| 3,3,14,14-Tetramethylhexadecanedioic acid \| 3,3,14,14-Tetramethyl-hexadecanedioic acid \|
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodentsi
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of FFA1 receptor

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Class Fatty Acyls
    - Subclass Fatty acids and conjugates

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Class	Fatty Acyls
Subclass	Fatty acids and conjugates
Intermediate Tree Nodes	Not available
Direct Parent	Long-chain fatty acids
Alternative Parents	Methyl-branched fatty acids Dicarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic acyclic compounds
Substituents	Long-chain fatty acid - Methyl-branched fatty acid - Branched fatty acid - Dicarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
Description	This compound belongs to the class of organic compounds known as long-chain fatty acids. These are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

FFAR1 Tchem Free fatty acid receptor 1 (1 Activities)

Discover Target: FFAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACLY Tclin ATP-citrate synthase (168 Activities)

Discover Target: ACLY

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Echs1 Enoyl-CoA hydratase 1 (14 Activities)

Discover Target: Echs1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)

Discover Target: fba

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3,3,14,14-tetramethylhexadecanedioic acid
INCHI	InChI=1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)
InChIKey	HYSMCRNFENOHJH-UHFFFAOYSA-N
Smiles	CC(C)(CCCCCCCCCCC(C)(C)CC(=O)O)CC(=O)O
Isomeric SMILES	CC(C)(CCCCCCCCCCC(C)(C)CC(=O)O)CC(=O)O
Molecular Weight	342.51
Reaxy-Rn	5037175
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5037175&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
A2426323	Certificate of Analysis	Dec 25, 2023	M288258
A2426324	Certificate of Analysis	Dec 25, 2023	M288258
A2426325	Certificate of Analysis	Dec 25, 2023	M288258
A2426326	Certificate of Analysis	Dec 25, 2023	M288258
A2426327	Certificate of Analysis	Dec 25, 2023	M288258
A2426328	Certificate of Analysis	Dec 25, 2023	M288258
A2426329	Certificate of Analysis	Dec 25, 2023	M288258
A2426331	Certificate of Analysis	Dec 25, 2023	M288258

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 34.25, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 34.25, Max Conc. mM: 100
Sensitivity	Moisture sensitive
Molecular Weight	342.500 g/mol
XLogP3	7.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	15
Exact Mass	342.277 Da
Monoisotopic Mass	342.277 Da
Topological Polar Surface Area	74.600 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	336.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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