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LX-4211 - ≥98%, high purity , Sodium/glucose cotransporter 2 inhibitor, CAS No.1018899-04-1, Sodium/glucose cotransporter 2 inhibitor

COA

Grade & Purity:

Moligand™

≥98%

Cas Number: 1018899-04-1
Molecular Weight: 424.94
PubChem CID: 24831714
PubChem SID: 504769865

In stock

Item Number

L127607

Grouped product items
SKU	Size	Availability	Price
L127607-5mg	5mg	3	$107.90
L127607-10mg	10mg	3	$162.90
L127607-25mg	25mg	3	$314.90
L127607-50mg	50mg	2	$489.90
L127607-100mg	100mg	2	$882.90

View related series

Membrane Transporter (607) Membrane Transporter/Ion Channel (1822) SGLT (27) Sodium/glucose cotransporter 1 Inhibitor (14) Sodium/glucose cotransporter 2 Inhibitor (12)

Basic Description

Synonyms	A852129 \| Sotagliflozin (LX4211) \| Sotagliflozin (LX-4211) \| 1018899-04-1 \| Tox21_501139 \| UNII-6B4ZBS263Y \| (2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(methylthio)-2H-pyran-3,4,5-triol;LX4211 \| DTXSID20144314 \| SOTAGLIFLOZIN [MI]
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	LX-4211 is a dual SGLT2/1 inhibitor; Antidiabetic agents.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Sodium/glucose cotransporter 2 inhibitor
Product Description	LX-4211 is a potent dual SGLT2/1 inhibitor; Antidiabetic agents.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic oxygen compounds
  - Class Organooxygen compounds
    - Subclass Carbohydrates and carbohydrate conjugates
      - Level5 Glycosyl compounds
        Level6 Phenolic glycosides

Kingdom	Organic compounds
Superclass	Organic oxygen compounds
Class	Organooxygen compounds
Subclass	Carbohydrates and carbohydrate conjugates
Intermediate Tree Nodes	Glycosyl compounds
Direct Parent	Phenolic glycosides
Alternative Parents	Diphenylmethanes Thioglycosides Phenoxy compounds Phenol ethers Alkyl aryl ethers Chlorobenzenes Aryl chlorides Oxanes Monosaccharides Monothioacetals Secondary alcohols Sulfenyl compounds Polyols Oxacyclic compounds Organochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Phenolic glycoside - Diphenylmethane - S-glycosyl compound - Phenoxy compound - Phenol ether - Alkyl aryl ether - Chlorobenzene - Halobenzene - Oxane - Benzenoid - Monosaccharide - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Monothioacetal - Secondary alcohol - Polyol - Oxacycle - Sulfenyl compound - Organoheterocyclic compound - Ether - Organosulfur compound - Alcohol - Hydrocarbon derivative - Organohalogen compound - Organochloride - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as phenolic glycosides. These are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Product Properties

ALogP	3.2

Associated Targets(Human)

SLC5A2 Tclin Sodium/glucose cotransporter 2 (7 Activities)

Discover Target: SLC5A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC5A1 Tclin Sodium/glucose cotransporter 1 (7 Activities)

Discover Target: SLC5A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc5a1 Sodium/glucose cotransporter 1 (11 Activities)

Discover Target: Slc5a1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc5a2 Sodium/glucose cotransporter 2 (17 Activities)

Discover Target: Slc5a2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504769865
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769865
IUPAC Name	(2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol
INCHI	InChI=1S/C21H25ClO5S/c1-3-26-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-18(24)17(23)19(25)21(27-20)28-2/h4-9,11,17-21,23-25H,3,10H2,1-2H3/t17-,18-,19+,20+,21-/m1/s1
InChIKey	QKDRXGFQVGOQKS-CRSSMBPESA-N
Smiles	CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)SC)O)O)O)Cl
Isomeric SMILES	CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)SC)O)O)O)Cl
Molecular Weight	424.94
Reaxy-Rn	21494945
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21494945&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
A2219726	Certificate of Analysis	Nov 10, 2023	L127607
A2219619	Certificate of Analysis	Nov 10, 2023	L127607
A2219578	Certificate of Analysis	Nov 10, 2023	L127607
A2219689	Certificate of Analysis	Nov 10, 2023	L127607
A2219616	Certificate of Analysis	Nov 10, 2023	L127607

Chemical and Physical Properties

Solubility	DMSO
Molecular Weight	424.900 g/mol
XLogP3	3.200
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	424.111 Da
Monoisotopic Mass	424.111 Da
Topological Polar Surface Area	104.000 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	476.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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