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LW 6 - ≥97%, high purity , CAS No.934593-90-5

1 Citations COA COA
    Grade & Purity:
  • ≥97%
In stock
Item Number
C275632
Grouped product items
SKU Size
Availability
 Price Qty
C275632-5mg
5mg
3
$77.90
C275632-10mg
10mg
3
$116.90
C275632-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$253.90
C275632-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$822.90
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Bulk Order  SDS  DATASHEET  Specification Sheet

HIF-1α inhibitor

View related series
Apoptosis (4276) cancer research (10) Glucose Metabolism (1943) HIF/HIF Prolyl-Hydroxylase (128) Metabolic Enzyme/Protease (4860)

Basic Description

Synonyms LW 6 | CAY10585
Specifications & Purity ≥97%
Biochemical and Physiological Mechanisms HIF-1α inhibitor (IC 50 values are 2.6 and 0.7 µM for Hep3B and AGS cell lines respectively). Suppresses transcription of HIF-1 target genes VEGF and erythropoietin at 10 µM. Attenuates hypoxia-induced ANP secretion.
Source Synthetic
Storage Temp Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
Superclass Benzenoids
Class Benzene and substituted derivatives
Subclass Benzoic acids and derivatives
Intermediate Tree Nodes Not available
Direct Parent Acylaminobenzoic acid and derivatives
Alternative Parents p-Hydroxybenzoic acid alkyl esters  Anilides  Phenoxy compounds  Phenol ethers  N-arylamides  Benzoyl derivatives  Alkyl aryl ethers  1-hydroxy-2-unsubstituted benzenoids  Methyl esters  Secondary carboxylic acid amides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular Framework Aromatic homopolycyclic compounds
Substituents Acylaminobenzoic acid or derivatives - P-hydroxybenzoic acid alkyl ester - P-hydroxybenzoic acid ester - Benzoate ester - Anilide - Phenoxy compound - Benzoyl - Phenol ether - N-arylamide - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Methyl ester - Carboxamide group - Carboxylic acid ester - Secondary carboxylic acid amide - Ether - Carboxylic acid derivative - Organonitrogen compound - Organic nitrogen compound - Carbonyl group - Organic oxide - Organooxygen compound - Hydrocarbon derivative - Organic oxygen compound - Aromatic homopolycyclic compound
Description This compound belongs to the class of organic compounds known as acylaminobenzoic acid and derivatives. These are derivatives of amino benzoic acid derivatives where the amine group is N-acylated.
External Descriptors Not available

Associated Targets(Human)

MDH1 Tchem Malate dehydrogenase cytoplasmic (119 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
AGS (1999 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PC-3 (62116 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HCT-116 (91556 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HepG2 (196354 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HeLa (62764 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
MDH2 Tchem Malate dehydrogenase, mitochondrial (179 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (820 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504768048
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504768048
IUPAC Name methyl 3-[[2-[4-(1-adamantyl)phenoxy]acetyl]amino]-4-hydroxybenzoate
INCHI InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29)
InChIKey BJRPPNOJYFZSLY-UHFFFAOYSA-N
Smiles COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4
Isomeric SMILES COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4
Molecular Weight 435.51
Reaxy-Rn 11008797
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11008797&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number Certificate Type Date Item
L2107862 Certificate of Analysis Sep 13, 2022 C275632
L2107859 Certificate of Analysis Sep 13, 2022 C275632
L2107841 Certificate of Analysis Sep 13, 2022 C275632
L2107850 Certificate of Analysis Sep 13, 2022 C275632
F2411027 Certificate of Analysis Nov 20, 2021 C275632

Chemical and Physical Properties

Solubility Soluble in DMSO to 10 mM
Sensitivity heat sensitive
Molecular Weight 435.500 g/mol
XLogP3 5.700
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 7
Exact Mass 435.205 Da
Monoisotopic Mass 435.205 Da
Topological Polar Surface Area 84.900 Ų
Heavy Atom Count 32
Formal Charge 0
Complexity 659.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Solution Calculators

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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