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| SKU | Size | Availability |
Price | Qty |
|---|---|---|---|---|
|
L647658-1mg
|
1mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$980.90
|
|
|
L647658-5mg
|
5mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$2,450.90
|
|
|
L647658-10mg
|
10mg |
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
|
$3,900.90
|
|
| Specifications & Purity | ≥95% |
|---|---|
| Biochemical and Physiological Mechanisms | Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase . By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the to |
| Storage Temp | Store at -20°C,Argon charged,Desiccated |
| Shipped In |
Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available. |
| Product Description |
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1). In Vitro Lumasiran reduced urinary oxalate excretion, the cause of progressive kidney failure in PH1. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Lumasiran is a subcutaneously administered, liver-directed RNA interference (RNAi) therapeutic agent. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| Smiles | [Lumasiran] |
|---|---|
| Molecular Weight | 16339.00 (AS: 7631.0 +SS: 8708.0) |
| Solubility | H2O : 100 mg/mL (Need ultrasonic) |
|---|