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LOX-IN-3 , CAS No.2409963-83-1

COA

Cas Number: 2409963-83-1
Molecular Weight: 280.32
PubChem CID: 146317833

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Item Number

L648579

Grouped product items
SKU	Size	Availability	Price
L648579-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$380.90
L648579-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
L648579-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,150.90
L648579-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,800.90

View related series

Monoamine Oxidase (116) Neuronal Signaling (3320)

Basic Description

Synonyms	2-Buten-1-amine, 3-fluoro-4-(8-quinolinylsulfonyl)-, (2Z)- \| GLXC-25899 \| (Z)-3-fluoro-4-(quinolin-8-ylsulfonyl)but-2-en-1-amine \| EX-A4912 \| AKOS040756172 \| 2409963-83-1 \| (Z)-3-fluoro-4-quinolin-8-ylsulfonylbut-2-en-1-amine \| HY-138625 \| PXS-5505 \| UNII
Biochemical and Physiological Mechanisms	LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research.
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads This product requires cold chain shipping. Ground and other economy services are not available.
Product Description	LOX-IN-3 is an orally active lysyl oxidase (LOX) inhibitor. LOX-IN-3 can be used for fibrosis, cancer and angiogenesis research In Vitro LOX-IN-3 dihydrochloride monohydrate (Compound 33) inhibits the bovine LOX and human LOXL2 activities with IC 50 values of <10 μM and <1 μM, respectively. LOX-IN-3 dihydrochloride monohydrate exhibits sustained inhibition of LOXL1 and LOXL2. LOX-IN-3 dihydrochloride monohydrate is less active against SSAO/VAP-1 and MAO-B activities. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo LOX-IN-3 dihydrochloride monohydrate (Compound 33) (30 mg/kg; orally; once) inhibits lysyl oxidase activity in rats . LOX-IN-3 dihydrochloride monohydrate (10 mg/kg; orally; daily for 14 days) reduces kidney fibrosis in unilateral ureteric obstruction (UUO) mice model . LOX-IN-3 dihydrochloride monohydrate (15 mg/kg; orally; daily for 21 days) reduces lung fibrosis in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats Dosage: 30 mg/kg Administration: Oral administration, single dose Result: Completely abolished lysyl oxidase activity. Plasma concentrations of tested compound are far below the IC 50 after 8 hours, the half-life of recovery is between 2-3 days (ear) and 24 hours (aorta). Animal Model: Unilateral ureteric obstruction (UUO) model of acute kidney fibrosis in mice Dosage: 10 mg/kg Administration: Oral gavage, daily for 14 days Result: Increased kidney weight and thickness and reduced the area of fibrosis. Animal Model: C57Bl/6 mice, Bleomycin-induced lung fibrosis model Dosage: 15 mg/kg Administration: Oral gavage, daily for 21 days Result: Significantly reduced the Ashcroft score and the lung weight. Form:Solid IC50& Target:IC 50 : <1 μM (human LOXL2), <10 μM (bovine LOX)

Names and Identifiers

IUPAC Name	(Z)-3-fluoro-4-quinolin-8-ylsulfonylbut-2-en-1-amine
INCHI	InChI=1S/C13H13FN2O2S/c14-11(6-7-15)9-19(17,18)12-5-1-3-10-4-2-8-16-13(10)12/h1-6,8H,7,9,15H2/b11-6-
InChIKey	DHXXLGDTPFPYRH-WDZFZDKYSA-N
Smiles	C1=CC2=C(C(=C1)S(=O)(=O)CC(=CCN)F)N=CC=C2
Isomeric SMILES	C1=CC2=C(C(=C1)S(=O)(=O)C/C(=C/CN)/F)N=CC=C2
Alternate CAS	2409963-83-1
PubChem CID	146317833
Molecular Weight	280.32

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	DMSO : 125 mg/mL (445.92 mM; Need ultrasonic)
Molecular Weight	280.320 g/mol
XLogP3	0.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	280.068 Da
Monoisotopic Mass	280.068 Da
Topological Polar Surface Area	81.400 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	430.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	1
Covalently-Bonded Unit Count	1

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