Aladdin SCI Paper Search Tool

The emergence of carbon dots has broadened the design and application of new room-temperature phosphorescence materials, but the mass production of long-lived color-tunable carbon dots-based phosphorescence materials (CDPMs) is still hindered by solvent dependence and time-consuming. In this work, a minute-level solid-phase synthesis strategy was proposed for the preparation of a series of CDPMs through pyrolyzing the mixture of boric acid and pimelic acid. By tuning the mass ratio of boric acid and pimelic acid, CDPMs with different room-temperature phosphorescence characterises can be obtained within 7 min. Preferably, the CDPMs-60 synthesized from the mass ratio of boric acid and pimelic acid of 60:1 exhibits a long afterglow length up to 10 s and has obvious phosphorescence chromatic aberrations following excitation at 254 and 365 nm, and phosphorescence lifetimes of CDPMs-60 in the blue and green band can reach 1030 ms and 555 ms, respectively. The CDPMs were further successfully applied for the information encryption and fabricating light emitting diodes based on their simple synthesis process, exceptional optical properties and low-toxicity. This study may provide a valuable reference for the facile synthesis and suitable commercial application of room temperature phosphorescence materials. Associated Products

Parkinson's disease (PD)-induced motor dysfunction and cognitive impairment are becoming increasingly common due to global population aging. However, efficient treatment strategies for these conditions are still lacking. Recent studies indicated that neuroinflammation and neuronal apoptosis could greatly worsen the symptoms of PD. Therefore, anti-apoptotic and anti-inflammatory drugs could be useful in the management of PD. In the present study, minocycline (MIN)-loaded Fe 3 O 4 nanoparticles (Fe 3 O 4 -MIN NPs) were prepared for the targeted treatment of PD. Owing to their near-infrared (NIR) irradiation-induced photothermal effects, the Fe 3 O 4 -MIN NPs could cross the blood-brain barrier (BBB), thus enhancing the delivery of Fe 3 O 4 -MIN NPs to the brain parenchyma. Subsequently, the Fe 3 O 4 -MIN NPs exerted strong anti-inflammatory effects and alleviated neuroinflammation in the brain. Furthermore, they exerted anti-oxidative effects, scavenging excessive reactive oxygen species in the brain parenchyma and thus protecting both dopaminergic and hippocampal neurons from neuroinflammation and apoptosis. Consequently, Fe 3 O 4 -MIN NPs + NIR treatment attenuated the motor dysfunction and cognitive impairment observed in PD mice. Notably, the Fe 3 O 4 -MIN NPs also showed high biocompatibility. Hence, these BBB-penetrating MIN-loaded Fe 3 O 4 NPs demonstrate great therapeutic potential for PD accompanied by cognitive impairment. Associated Products

Chitin, a natural organic compound with content slightly lower than cellulose, is also known for chitosan, a substance derived from chitin through deacetylation. In this experiment, preliminary screening was conducted using the plate discoloration circle method, leading to the selection of a high-yield CDA-producing strain from 28 candidates through rescreening. Morphological characteristics and 16S rDNA sequence analysis revealed 99.93% homology with Enterobacter sichuanensis strain N24, thus naming this strain Enterobacter strain ZCDA27. Initial fermentation of the strain yielded CDA activity of 9.29 U/mL. Single-factor optimization was then performed, followed by a PB test to screen for significant factors affecting enzyme production. The response surface method was used to further optimize the fermentation conditions. The optimal fermentation conditions for the carbon source, nitrogen source, metal ion, fermentation temperature, time, liquid volume, and initial pH were explored. Significant factors affecting enzyme production, including MgSO 4 , initial medium pH, and fructose levels, were identified using the PB test. Finally, the fermentation conditions of ZCDA27 were optimized using the Box-Behnken design combined with RSM, which comprised fructose at 1.020%, magnesium sulfate at 0.016%, and peptone at 1%. The fermentation conditions included a temperature of 37, initial pH of 7.1, rotation speed of 140 ×  g , fermentation time of 28 h, inoculation amount of 2%, and liquid volume of 40%. Under these conditions, the enzyme activity of ZCDA27 reached 14.52 U/mL, a 1.6-fold increase from the pre-optimization levels. In summary, this study provides an experimental foundation for further development and application of Enterobacter spp. ZCDA27 CDA. Associated Products

Xanthates , common mining flotation reagents, strongly bind thiophilic metals such as copper (Cu), lead (Pb), cadmium (Cd), and zinc (Zn) and consequentially change their bioavailability and mobility upon their discharge into the environment. However, accurate quantification of the metal-xanthate complexes has remained elusive. This study develops a novel and robust method that realizes the accurate quantification of the metal-xanthate complexes resulted from single and multiple reactions of three typical xanthates (ethyl, isopropyl, and butyl xanthates) and four thiophilic metals (Cu, Pb, Cd, and Zn) in water samples. This method uses sulfur (S 2- ) dissociation, followed by tandem solid phase extraction of C 18 + PWAX and subsequent LC-MS/MS analysis. It has a wide linearity range (1–1000 μg/L, R 2 ≥ 0.995), low method detection limits (0.002–0.036 μg/L), and good recoveries (70.6–107.0 %) at 0.01–10 mg/L of xanthates. Applications of this method showed ubiquitous occurrence of the metal-xanthate complexes as the primary species in flotation wastewaters, which the concentrations were 4.6–28.9-fold higher than those previously determined. It is the first quantitative method established for the analysis of metal-xanthate complexes in water samples, which is of great importance to comprehensively understand the fate and risks of xanthates in the environment. Associated Products

A novel carbonyl reductase from Hyphopichia burtoni ( Hb KR) was discovered by gene mining. Hb KR is a NADPH-dependent dual function enzyme with reduction and oxidation activity belonging to SDR superfamily. Hb KR strictly follows Prelog priority in the reduction of long-chain aliphatic keto acids/esters containing remote carbonyl groups, such as 4-oxodecanoic acid and 5-oxodecanoic acid, producing ( S )- γ -decalactone and ( S )- δ -decalactone in >99 % e.e. Tailor-made engineering of Hb KR was conducted to improve its catalytic efficiency . Variant F207A/F86M was obtained with specific activity of 8.37 U/mg toward 5-oxodecanoic acid, which was 9.7-fold of its parent. Employing F207A/F86M, 100 mM 5-oxodecanoic acid could be reduced into optically pure ( S )- δ -decalactone. Molecular docking analysis indicates that substitution of aromatic Phe with smaller residues renders sufficient space for accommodating substrates in a more stable conformation. This study offers an efficient biocatalyst for the biosynthesis of ( S )-lactones, and provides guidance for engineering carbonyl reductases toward structurally hindered substrates. Associated Products

1-Deoxynojirimycin (DNJ), a primary active component in mulberry leaves, has garnered significant attention due to its unique structure and notable pharmacological properties. Our previous investigations have elucidated the biosynthetic pathways of DNJ from lysine to 2-methylpiperidine. However, the hydroxylation process and its underlying mechanisms remain elusive. In this study, five CYP450s hydroxylase genes significantly correlated ( P  < 0.05) with DNJ content in mulberry leaves at various time were screened through transcriptome profile. MaCYP71BG22 was first cloned and functionally characterized. This gene was shown to specifically catalyze the stereoselective hydroxylation of ( R )-2-methylpiperidine at the C4-position to produce (2 R , 4 R )-2-methylpiperidin-4-ol. In hairy roots of mulberry, overexpression of MaCYP71BG22 increased DNJ accumulation, while virus-induced gene silencing (VIGS) decreased its production. Furthermore, structural-function analysis pinpointed a critical residue, G460, in MaCYP71BG22, mutation of this residue to G460E enhanced the enzyme's catalytic efficiency. This study represents the first report of a CYP450 hydroxylase involved in the biosynthesis of piperidine alkaloids in mulberry leaves, and demonstrates that MaCYP71BG22 selectively catalyzes the C4-stereoselective hydroxylation of ( R )-2-methylpiperidine in DNJ biosynthesis. These findings further elucidate the DNJ biosynthetic pathway and provide new insights into the stereo- and regio-selective hydroxylation abilities of CYP450s hydroxylase in DNJ biosynthesis. Associated Products

The open circuit voltage ( V OC ) losses at multiple interfaces within perovskite solar cells (PSCs) limit the improvements in power conversion efficiency (PCE). Herein, a tailored strategy is proposed to reduce the energy offset at both hetero-interfaces within PSCs to decrease the V OC losses. For the interface of perovskite and electron transport layer where exists a mass of defects, it uses the pyromellitic acid to serve as a molecular bridge, which reduces non-radiative recombination and energy level offset. For the interface of perovskite and hole transport layer, which includes a passivator of PEAI, the detrimental effect (negative shift of work function) of PEAI passivation and optimizing the interface energy level alignment are neutralized by incorporating (2-(4-(bis(4-methoxyphenyl)amino)phenyl)-1-cyanovinyl)phosphonic acid. Owing to synergistically reduced hetero-interface energy offset, the PSCs achieve a PCE of 25.13%, and the V OC is increased from 1.134 to 1.174 V. In addition, the resulting PSCs possess enhanced stability, the unencapsulated PSCs can maintain ≈96% and ≈97% of their initial PCE after 2000 h of aging under ambient conditions and 210 h under operation conditions. Associated Products

Transparent wood derived from renewable biomass resources has an enormous potential for utilizing in constructions, electrons devices, energy storage, etc. However, due to its high polymer content, the currently described transparent wood could not be developed in a sustainable manner. Herein, a feasible strategy for synthesizing compressed transparent wood was proposed to minimize the content of polymerized poly(methyl methacrylate) in composites, involving the poly(methyl methacrylate) partial-filling into the delignified wood and densification . This synthesis method prompted a substantial reduction of poly(methyl methacrylate) content (58.8%) in the obtained compressed transparent wood contrasted with the typical transparent wood (91.8% poly(methyl methacrylate) content). Besides, an ideal optical transmittance of 77.9% with 0.4 mm thickness and an optical haze of 49.2% with 0.7 mm thickness at 800 nm wavelength were achieved. Also, the improved tensile strength and flexural strength of compressed transparent wood were up to 85.0 MPa and 145.3 MPa, respectively. Additionally, a comparative life cycle assessment was conducted to assess the environmental impacts. The total environmental impact score was separately reduced by 23%, and 28% compared to the typical transparent wood and poly(methyl methacrylate) polymer, suggesting the feasibility of sustainable manufacture of transparent wood materials by decreasing polymer content. The compressed transparent wood also showed much lower thermal conductivities (0.28–0.31 W/mk) than glass and contributed to offering uniform illumination. Associated Products

Porous hollow carbon sphere (HCS) is an attractive catalyst support for oxygen reduction reaction (ORR) due to its large specific surface area for active site anchoring, porous and hollow structure for active site exposure and mass transfer. However, due to the high transfer resistance for exogenous heteroatoms into HCS, most of active sites are usually loaded on the outer surface of HCS, leading to the decrease of active site density and the aggregation of heteroatomic particles. In this work, we proposed that accompanied with the decrease of liquid/solid interfacial energy by changing solvent composition during impregnation, penetration of exogenous heteroatoms-containing solution was facilitated in HCS, resulting in increased density of uniformly-dispersed Fe−N x active site by 58 %. Taking advantage of high-content and well-dispersed active site, structure-derived porosity for ion transfer and active site exposure, this HCS-derived catalyst (Fe-HCS@C 2 H 5 OH) exhibited positive onset and half-wave potentials of 0.953 V and 0.901 V (vs. RHE), as well as high power density of 20.17 ± 0.31 mW cm −2 when applied in membrane-less direct formate fuel cell cathode, surpassing those of commercial Pt/C and the state-of-the-art carbonaceous catalysts. This strategy of interfacial energy control provides a new stepping-stone for the synthesis of high-performance electrocatalysts. Associated Products

Poly (ADP-ribose) polymerase 1 (PARP1) catalyzes poly (ADP) ribosylation reaction, one of the essential post-translational modifications of proteins in eukaryotic cells. Given that PARP1 inhibition can lead to synthetic lethality in cells with compromised homologous recombination, this enzyme has been identified as a potent target for anti-cancer therapeutics. However, the clinical application of existing PARP1 inhibitors is restrained by side effects associated with DNA trapping and off-target effects, highlighting the need for improved therapeutic strategies. By integrating protein degradation technology, we synthesized a PROTAC molecule 180055 based on the Rucaparib junction and VHL ligand, which efficiently and selectively degraded PARP1 and inhibited PARP1 enzyme activity without a noticeable DNA trapping effect. Furthermore, 180055 kills tumor cells carrying BRCA mutations with a minor impact on the growth of normal cells both in vitro and in vivo. This suggests that 180055 is a PARP1-degrading compound with excellent pharmacological efficacy and extremely high biological safety that deserves further exploration and validation in clinical trials. Associated Products

The conversion of biomass glucose to formic acid (FA) has been demonstrated as a promising sustainable manufacturing process, further enhanced by the application of the microchannel reactor technology. However, FA decomposition remains a challenge, limiting FA yield in the catalytic oxidation process. To gain insights into the reaction kinetics of FA decomposition, the effects of reaction temperature, O 2 pressure, residence time, catalyst content (H 5 PV 2 Mo 10 O 40 ), and pH value on FA decomposition were systematically investigated. The results showed that FA decomposition involved hydrothermal decomposition, acid decomposition, and catalytic oxidative decomposition. When the reaction temperature exceeded 160 °C, the degree of FA decomposition increased significantly. High oxygen partial pressure, long residence time, and high catalyst content all had a significant positive impact on the FA decomposition. The decomposition of FA in this process was found to follow second-order kinetics, with an apparent activation energy of 154.1 kJ/mol. Based on these findings, a novel strategy was proposed and evaluated by coupling reaction and extraction processes facilitated by a gas–liquid-liquid three-phase flow configuration in a microchannel reactor, enabling the in-situ extraction of FA from the strong oxidative environment using isoamyl alcohol. By minimizing the oxidative decomposition of FA during FA production, this development provides an effective means to enhance the process efficiency of biomass-to-FA production. Associated Products

Current brain tumor treatments are limited by the skull and BBB, leading to poor prognosis and short survival for glioma patients. We introduce a novel minimally-invasive brain tumor suppression (MIBTS) device combining personalized intracranial electric field therapy with in-situ chemotherapeutic coating. The core of our MIBTS technique is a wireless-ultrasound-powered, chip-sized, lightweight device with all functional circuits encapsulated in a small but efficient “Swiss-roll” structure, guaranteeing enhanced energy conversion while requiring tiny implantation windows ( ~ 3 × 5 mm), which favors broad consumers acceptance and easy-to-use of the device. Compared with existing technologies, competitive advantages in terms of tumor suppressive efficacy and therapeutic resolution were noticed, with maximum ~80% higher suppression effect than first-line chemotherapy and 50–70% higher than the most advanced tumor treating field technology. In addition, patient-personalized therapy strategies could be tuned from the MIBTS without increasing size or adding circuits on the integrated chip, ensuring the optimal therapeutic effect and avoid tumor resistance. These groundbreaking achievements of MIBTS offer new hope for controlling tumor recurrence and extending patient survival. Associated Products