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lartesertib , CAS No.2020089-41-0, Inhibitor of ATM serine/threonine kinase;Inhibitor of protein kinase; DNA-activated; catalytic subunit

COA

Grade & Purity:

Moligand™

Cas Number: 2020089-41-0
PubChem CID: 122599280

In stock

Item Number

L611450

Grouped product items
SKU	Size	Availability	Price	Qty
L611450-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$370.90
L611450-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,280.90

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ATM serine/threonine kinase Inhibitor (8) DNA Damage (697) protein kinase，DNA-activated，catalytic subunit Inhibitor (15)

Basic Description

Synonyms	Lartesertib \| 2495096-26-7 \| M 4076 [WHO-DD] \| EX-A6934 \| BDBM418555 \| MS-28119 \| 8-(1,3-Dimethyl-1H-pyrazol-4-yl)-1-(3-fluoro-5-methoxypyridin-4-yl)-7-methoxy-3-methyl-1,3-dihydro2H-imidazo[4,5-c]quinolin-2-one \| 8-(1,3-dimethyl-1H-pyrazol-4-yl)-1-(3-flu
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ATM serine/threonine kinase;Inhibitor of protein kinase; DNA-activated; catalytic subunit

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Imidazoquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Imidazoquinolines
Intermediate Tree Nodes	Not available
Direct Parent	Imidazoquinolines
Alternative Parents	Imidazo-[4,5-c]pyridines Anisoles Pyridinones Alkyl aryl ethers N-substituted imidazoles Aryl fluorides Pyrazoles Heteroaromatic compounds Ureas Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Imidazoquinoline - Imidazo-[4,5-c]pyridine - Imidazopyridine - Anisole - Pyridinone - Alkyl aryl ether - Benzenoid - Pyridine - N-substituted imidazole - Aryl halide - Aryl fluoride - Heteroaromatic compound - Pyrazole - Imidazole - Azole - Urea - Azacycle - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as imidazoquinolines. These are aromatic heterocyclic compounds containing an imidazole ring fused to a quinoline ring system. In some configurations, the imidazole ring shares a nitrogen atom with the quinoline moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PRKDC Tchem DNA-dependent protein kinase catalytic subunit (0 Activities)

Discover Target: PRKDC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATM Tchem Serine-protein kinase ATM (0 Activities)

Discover Target: ATM

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	8-(1,3-dimethylpyrazol-4-yl)-1-(3-fluoro-5-methoxypyridin-4-yl)-7-methoxy-3-methylimidazo[4,5-c]quinolin-2-one
INCHI	InChI=1S/C23H21FN6O3/c1-12-15(11-28(2)27-12)13-6-14-17(7-19(13)32-4)26-9-18-21(14)30(23(31)29(18)3)22-16(24)8-25-10-20(22)33-5/h6-11H,1-5H3
InChIKey	WNEFOSMCGCLLJU-UHFFFAOYSA-N
Smiles	Cc1nn(cc1c1c(cc2c(c1)c1c(cn2)n(c(=O)n1c1c(cncc1OC)F)C)OC)C
Isomeric SMILES	CC1=NN(C=C1C2=C(C=C3C(=C2)C4=C(C=N3)N(C(=O)N4C5=C(C=NC=C5OC)F)C)OC)C
PubChem CID	122599280

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