L-α-Lysophosphatidylcholine (from egg yolk) - ≥99%, Type I, powder, high purity , CAS No.9008-30-4, Activator of ASIC3;Activator of K 2P10.1;Activator of TRPC5;Activator of TRPC6;Activator of TRPV2
L-α-Lysophosphatidylcholine (from egg yolk) - ≥99%, Type I, powder, high purity , CAS No.9008-30-4, Activator of ASIC3;Activator of K 2P10.1;Activator of TRPC5;Activator of TRPC6;Activator of TRPV2
Lysophosphatidylcholine is a major component of oxidized low density lipoprotein and is associated with a variety of inflammatory responses including atherosclerosis. To demyelinate neurons in the spinal cord and to study the processes that underlie myeli
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
ACTIVATOR
Mechanism of action
Activator of ASIC3;Activator of K 2P10.1;Activator of TRPC5;Activator of TRPC6;Activator of TRPV2
Product Description
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.
This compound belongs to the class of organic compounds known as 1-acyl-sn-glycero-3-phosphocholines. These are glycerophosphocholines in which the glycerol is esterified with a fatty acid at O-1 position, and linked at position 3 to a phosphocholine.
External Descriptors
Monoacylglycerophosphocholines
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
2 Citations
H2223376